Sandoval Altamirano Catalina Paz

Email: 
catalina.sandoval.a@usach.cl

Considering that a substantial number of biological process (both physiological and pathological process) are governed by carbohydrate-protein interactions and that the single interaction between a protein and a saccharide is weak, in the biological processes, multiple interaction occurs increasing global avidity of the system (phenomenon knowns as multivalence). The focus of her research is to design and synthetize multivalent systems with the capability of specifically interact with a specific proteins (combining both, a high affinity with a high specificity), followed by the determination of kinetic and thermodynamic parameters involved in the interaction. Without abandoning the perspective of using novel multivalent systems to detect cancer cell lines and/or destroy or disrupt the interaction of some specific pathogens.

Surface plasmon resonance (SPR), Isothermal titration calorimetry (ITC), Circular dichroism and spectroscopic measurements of exogen or endogen probes have been used for evaluating and characterizing carbohydrate-protein interactions.

Línea(s) de investigación: 
Síntesis y caracterización de sistemas multivalentes de carbohidratos, Termodinámica y cinética de la interacción carbohidrato-proteína, Fotoquímica y Fotofísica de moléculas orgánicas en diferentes entornos.
Jerarquía: 
Asistente
Grados académicos /educación: 
Doctora en Química, Universidad de Chile, 2017
Química, Universidad de Chile, 2012
Licenciada en Química, Universidad de Chile, 2011
Publicaciones: 

13. Castro-Castillo, Vicente., Gajardo, Javier., Sandoval-Altamirano, Catalina., Gratton, Enrico., Sanchez, Susana., Malacrida, Leonel., Günther, Germán. CAPRYDAA, an anthracene dye analog to LAURDAN: a comparative study using cuvette and microscopy. Journal of Materials Chemistry B 2020, 8, 88-99.

12. Saldías, M., Guzmán, N., Palominos, F., Sandoval-Altamirano, C., Günther, G., Pizarro, N., Vega, A. Electronic and Photophysical Properties of Re I (CO) 3 Br Complexes Modulated by Pyrazolyl–Pyridazine Ligands. ACS OMEGA 2019, 4, 4679-4690.

11. Sandoval-Altamirano, C., Sánchez, S. A., Pizarro, N., Morales, J., Günther, G. Curvophilic-curvophobic balance of monoalkyl-mannosides determines the magnitude of disturbance promoted in synthetic bilayer. Journal of Molecular Liquids 2019, 282, 347-355.

10. Pizarro, N. Saldías, M., Guzmán, N., Sandoval-Altamirano, C., Kahlal, S., Sillard, J. Y., Hamon, J. R., Vega, A. 1 IL and 2 MLCT excited states modulated by H+: structure and photophysical properties of [(2-bromo-5-(1H-pyrazol-1-yl)pyrazine)Re(CO) 3 Br]. New Journal of chemistry 2019, 43, 2449-2457.

9. Méndez-Torres, A., Sandoval-Altamirano, C., Sánchez-Arenillas, M., Marco, J.F., Yañéz, C. Amino β-cyclodextrins immobilized on gold surfaces: Effect of substituents on host-guest interactions. Electrochimica Acta 2018, 282, 860-869.

8. Sandoval-Altamirano, C., Sanchez, S. A., Pizarro, N., Morales, J., Gunther, G., Alkyl-mannoside derivatives: glycolipids able to form big size aggregates. Journal of Physical Organic Chemistry, 2018. https://doi.org/10.1002/poc.3822

7. Pizarro, N., Prado, G., Saldías, M., Sandoval-Altamirano, C., Vega, A. The effect of pyrazolyl substituents on the photophysical and photochemical properties of pyrazine derivatives. Photochemistry and Photobiology 2018, 94, 845-852.

6. Sandoval-Altamirano, C., De la Fuente, J.R., Berrios, E., Sanchez, S. A., Pizarro, N., Morales, J., Gunther, G., Photophysical Characterization of Hydroxy and Ethoxy phenalenone derivatives. Journal of Photochemistry and Photobiology A 2018, 353, 349-357.

5. Cumsille, S., Morales, J., Sandoval-Altamirano, C., Günther, G., Vega, A., Pizarro, N. Substituent Effect of Side Chains on the Photochemical Behavior of a New Generation 1,4-Dihydropyridine: Lercanidipine. Journal of photochemistry and Photobiology A: Chemistry 2018, 353, 1-9.

4. Gunther, G. Herlax, V., Lillo, P. M., Sandoval-Altamirano, C., Belmar, L. N., Sánchez, S. A. Study of rabbit erythrocytes membrane solubilization by sucrose monomyristate using Laurdan and phasor analysis. Colloids and surface B: biointerface 2018, 161, 375-385

3. Sandoval- Altamirano, C., Sanchez, S. A., Ferreyra, N. F., Gunther, G. Understanding the interaction of Concanavalin A with mannosyl glycoliposomes: A surface plasmon resonance and fluorescence study. Colloids and surface B: Biointerfaces 2017, 158, 539-546.

2. Sandoval, C., Arriagada, F. S., De la Fuente, J. R., Sanchez, S. A., Morales, J., Pizarro, N., Nonell, S., Gunther, G. Synthesis, physicochemical and photophysical characterization of 4-(1-pyrenyl)-butyl-a-D-mannopyranoside. Journal of the Brazilian Chemical Society 2016, 27 (2), 402-410.

1. Sandoval, C., Ortega, A., Sanchez, S., Morales, J., Gunther, G. Structuration in the interface of direct and reversed micelles of sucrose esters, studied by fluorescent techniques. Plos One 2015. doi.org/10.1371/journal.pone.0123669

Proyectos: 

Investigadora responsable

  • Fondecyt 3190206 “Síntesis y caracterización de nuevos sensores fluorescentes de glico-pilar[5]arenos para la interacción específica con proteínas” 2019-2022.

Co-investigadora

  • Fondecyt 1200597 “Blue-shifted "glycosensitizers" derived from Phenalenone: synthesis, characterization and lectin interaction” 2020-2024