Ibacache Rojas Juana Andrea

Email: 
juana.ibacache.r@usach.cl
Teléfono: 
27 181 145
Línea(s) de investigación: 
Diseño, Síntesis y Evaluación Antitumoral de Compuestos quinonicos N-heterocíclicos con actividad antitumoral.
Jerarquía: 
Asociado
Grados académicos /educación: 
Postdoctorado en Química, Pontificia Universidad Católica de Chile, 2011-2013
- Doctor en Química, Pontificia Universidad Católica de Chile, 2010
- Diplomado en docencia universitaria.
Publicaciones: 

17.- Judith Faundes, Michelle Muñoz-Osses, Pilar Morales, Federico Tasca, Cesar Zuñiga Loyola, Mario Faundez, Carolina Mascayano and Juana A. Ibacache*. Effect of substituents and chain length in amino-1,4-naphthoquinones on glutathione-Stransferase inhibition: molecular docking and electrochemical perspectives: a structure–activity study. New J. Chem., 2022, 46, 21648

16.- Beatriz Valenzuela, Almendra Benavides,  Francisco Leyton, Franco Moreno, Marcos Cortés, Juana A. Ibacache*. Evaluation of bactericidal activity of 7-arylaminoisoquinolin-5,8 -quinones against Piscirickettsia salmonis. J. Fish. Dis. 2022; 00:1–5

15.- Juana Andrea Ibacache*, Jaime A. Valderrama, Judith Faundes, Alex Danniman, Francisco J. Recio and Cesar Zuñiga. Green Synthesis and Electrochemical Properties of Mono- and Dimers Derived from Phenylaminoisoquinolinequinones. Molecules 2019, 24 (23), 4378

14. Juana Andrea Ibacache*; Judith Faundes; Margarita Montoya; Sophia Mejías; and Jaime A. Valderrama. Preparation of Novel Homodimers Derived from Cytotoxic Isoquinolinequinones. A Twin Drug Approach. Molecules, 2018, 23, 439.

13. Synthesis and Antiproliferative Evaluation of New Aminoisoquinolinequinones Derived from p-Phenylenediamine, Benzidine and Dapsone. Juana A Ibacache*, Jaime A Valderrama,  Margarita Montoya, Rodrigo Segura, Judith Faundes and Sophia Mejías. J. Chem. Pharm. Res., 2017, 9(6):127-134.

12. Synthesis and Antiproliferative Evaluation of New Aminoisoquinolinequinones Derived from p-Phenylenediamine, Benzidine and Dapsone. Juana A Ibacache*, Jaime A Valderrama, Margarita Montoya, Rodrigo Segura, Judith Faundes and Sophia Mejías. J. Chem. Pharm. Res., 2017, 9(6):127-134.

11. Antiproliferative  activity of New 6-bromine derivatives of 7-anilino-1-arylisoquinolinequinones. J.A. Ibacache*,  J.A.Valderrama, V. Arancibia, C. Theoduloz, G. Muccioli and J. Benites. Journal of the Chilean Chemical Society. Aceptado 2016

10. Synthesis and antiproliferative evaluation of 8-anilino-6-arylphenanthridinequinones. Juana A. Ibacache*, Jaime A. Valderrama, Cristina Theoduloz, Julio Benites and Giulio Mucciolli. Journal of Chemical and Pharmaceutical Research, 2016, 8(8):824-831.

9. Jaime A Valderrama, Juana Andrea Ibacache & Cristina Theoduloz. Synthesis and antiproliferative evaluation of new isomeric ellipticine quinones. Boletín Latinoamericano y del Caribe de Plantas Medicinales y Aromáticas 13 (6): 566 - 574. 2014.

8. Juana Andrea Ibacache*; Virginia Delgado; Julio Benites; Cristina Theoduloz, Verónica Arancibia; Giulio G. Muccioli and Jaime Valderrama*, (2014) Synthesis, Half-Wave Potentials and Antiproliferative Activity of 1-Aryl-substituted Aminoisoquinolinequinones,Molecules: 19, 726-739.

7. Delgado, V.; Ibacache, J.A.; Arancibia, V.; Theoduloz, C.; Valderrama, J.A.*, (2013) Synthesis and in vitro antiprolifarative activity of new phenylaminoisoquinolinequinones against cancer cell lines. Molecules. 18: 721-734. ISI IF= 2,386

6. Delgado, V.; Ibacache, J.A.; Theoduloz, C.; Valderrama, J.A.*, (2012) Part 49. Synthesis and in vitro cytotoxic evaluation of aminoquinones structurally related to marine isoquinolinequinones. Molecules. 17: 7042-7056. ISI IF= 2,386

5. Monsalve*, F.A.; Valderrama, J.A.; Vásquez, D.; Ibacache, J.A.; Rodríguez, J.A.; Leiva, E., (2012) Inhibition of human topoisomerase I and activation of caspase- 3 by aza-angucyclinones and arylaminopyrido(4,5-c)isoquinoline-7,10-quinones. Int. J. Mol. Med., 1, 151-156. ISI IF 1,573

4. Valderrama, J.A.*; Ibacache, J.A; Rodríguez, J.A.; Theoduloz, C.; Benites, J., (2011) Studies on quinones. Part 47. Synthesis of novel phenylaminophenanthridinequinones as potential antitumor agent.  European Journal of Medicinal Chemistry, 46, 3398-3409. ISI IF= 3,346

3. Valderrama, J.A*.; Ibacache, J.A., (2009) Regiochemical control in the amination reaction of 3,4-dihydrophenanthridine-1,7,10(2H)-triones. Tetrahedron Letters, 50, 4361-4363. ISI IF= 2,683

2. Valderrama, J.A*.; Ibacache, J.A.; Rodríguez, J.A.; Theoduloz, C., (2009) Studies on quinones. Part 45. Novel 7-aminoisoquinoline-5,8-quinone derivatives with antitumor properties on cancer cell lines. Bioorg. Med. Chem., 17, 2894-2901. ISI IF= 2,921

1. Valderrama, J.A*.; Ibacache, J.A.; Rodríguez, J.A.; Theoduloz, C. and Schmeda-Hirshmann, G., (2008) Synthesis and Cytotoxic Evaluation of arylamino- and alkylaminoisoquinolinquinones. Drugs of the Future, 33, 0377-8282. ISI IF= 0.52

Proyectos: 

Investigador responsable

  1. FONDECYT N° 11140063 (2014-2017), Synthesis and electronic properties of novel  donor-acceptor n n-bis-isoquinoyl aryldiamine derivatives
  2. FONDECYT POSTDOCTORAL 3120023 Synthesis and structure-activity relationships of heteroarylisoquinoline- and phenanthridinequinones as antitumor agents, 2011-2013.
  3. Proyecto DICYT 021341IR Diseño, sintesis y propiedades redox de diamina N,N- diisoquinoil sustituidas
  4. CONICYT AT-24080014 Apoyo de tesis doctoral Diseño, Síntesis y Evaluación antitumoral de aminoisoquinolin- y fenantridinquinonas, 2008-2010
Otras actividades relevantes: 

Comité de sociedades científicas

  • Director secretario Sociedad Chilena de Neurociencias (2005-2010)