Clase abierta y gratuita: Fármacos II y el nuevo escenario para los medicamentos y dispositivos médicos
Vásquez Guzmán Claudio Christian
Email:
claudio.vasquez@usach.cl
Teléfono:
27 181 117
Línea(s) de investigación:
Microbiología Molecular
Jerarquía:
Titular
Grados académicos /educación:
Doctor en Ciencias Biológicas, P. Universidad Católica de Chile, 1983
Bioquímico, Universidad de Chile, 1977
Publicaciones:
- Rodríguez-Rojas, F., Díaz-Vásquez, W.A., Undabarrena, A., Muñoz-Díaz, P., Arenas, F.A., and Vásquez, C.C. (2015). Mercury-mediated cross-resistance to tellurite in Pseudomonas spp. isolated from the Chilean Antarctic territory. Metallomics 8: 108-117.
- Wansapura, P.T., Díaz-Vásquez, W.A., Vásquez, C.C., Pérez-Donoso, J.M., and Chasteen, T.G. (2015). Thermal and photo stability of glutathione-capped cadmium telluride quantum dots. J. Appl. Biomater. Funct. Mater. 13: e248-e252.
- Sandoval, J.M., Arenas, F.A., García, J.A., Díaz-Vásquez, W.A., Valdivia-González, M., Sabotier, M., and Vásquez C.C. (2015). Escherichia coli 6-phosphogluconate dehydrogenase aids in tellurite resistance by reducing the toxicant in a NADPH-dependent manner. Microbiol. Res. 177: 22-27.
- Elías, A., Díaz-Vásquez, W.A., Abarca-Lagunas, M.J., Chasteen, T.G., and Vásquez, C.C. (2015). The ActP acetate transporter acts prior to the PitA phosphate carrier in tellurite uptake by Escherichia coli. Microbiol. Res. 177: 21-25.
- Monrás, J.P., Collao, B., Molina-Quiroz, R.C., Pradenas, G.A., Saona, L.A., Durán-Toro, V., Ordenes-Aenishanslins, N., Venegas, F.A., Loyola, D.E., Bravo, D., Calderón, P.F., Calderón, I.L., Vásquez, C.C., Chasteen, T.G., López, D.A., and Pérez-Donoso, J.M. (2014). Microarray analysis of the Escherichia coli response to CdTe-GSH Quantum Dots: understanding the bacterial toxicity of semiconductor nanoparticles. BMC Genomics 15: 1099.
- Pugin, B., Cornejo, F.A., Muñoz-Díaz, P., Muñoz-Villagrán, C.M., Vargas-Pérez, J.I., Arenas, F.A., and Vásquez, C.C. (2014). Glutathione reductase-mediated synthesis of tellurium-containing nanostructures exhibiting antibacterial properties. Appl. Environ. Microbiol. 80: 7061-7070.
- Díaz-Vásquez, W., Abarca-Lagunas, M.J., Cornejo, F.A., Pinto, C.A., Arenas, F.A., and Vásquez, C.C. (2014). Tellurite-mediated damage to the Escherichia coli electron transport chain components. Arch. Biochem. Biophys. 566: 67-75.
- Gallardo, C., Monrás, J.P., Plaza, D.O., Collao, B., Saona, L.A., Durán-Toro, V., Venegas, F.A., Soto, C., Ulloa, G., Vásquez, C.C., Bravo, D., and Pérez-Donoso J.M. (2014). Low-temperature biosynthesis of semiconductor, fluorescent CdS nanoparticles by oxidative stress-resistant Antarctic bacteria. J. Biotechnol. 187:108-115.
- Molina-Quiroz, R.C., Loyola, D., Díaz-Vásquez, W.A., Arenas, F.A., Urzúa, U., Pérez-Donoso, J.M., and Vásquez, C.C. (2014). Global transcriptomic analysis uncovers a switch to anaerobic metabolism in tellurite-exposed Escherichia coli.Res. Microbiol. 165: 566-570.
- Arenas, F.A., Leal, C.A., Pinto, C.A., Arenas-Salinas, M.A., Morales, W.A., Cornejo, F.A., Díaz-Vásquez, W.A., and Vásquez C.C. (2014). On the mechanism underlying tellurite reduction by Aeromonascaviae ST dihydrolipoamide dehydrogenase. Biochimie 102: 174-182.
- Pugin, B., Cornejo, F.A., García, J.A., Díaz-Vásquez, W.A., Arenas, F.A., and Vásquez, C.C. (2014). Thiol-mediated enhancement of tellurite toxicity in Staphylococcus aureus. Adv. Microbiol. 4: 183-190.
- Díaz-Vásquez, W.A., Abarca-Lagunas, M.J., Arenas, F.A., Pinto, C.A., Cornejo, F.A., Wansapura, P.T., Appuhamillage, G.A., Chasteen, T.G., and Vásquez, C.C. (2014). Tellurite reduction by Escherichia coli NDH-II dehydrogenase results in superoxide production in membranes of toxicant-exposed cells. Biometals 27: 237-246.
- Arenas, F.A., Pugin, B., Henríquez, N.A., Arenas, M.A., Díaz-Vásquez, W.A., Pozo, F., Muñoz, C.M., Pérez-Donoso, J.M., and Vásquez, C.C. (2014). Isolation, identification and characterization of highly tellurite-resistant, tellurite-reducing bacteria from Antarctica. Polar Sci. 8: 40-52.
- Gautier, J.L., Monrás, J.P., Osorio-Román, I.O., Vásquez, C.C., Bravo, D., Herranz, T., Marco, JF., and Pérez-Donoso, JM. (2013). Surface characterization of GSH-CdTe quantum dots. Mat. Chem. Phys. 140: 113-118.
- Reinoso, C.A., Appanna, V.D., and Vásquez, C.C. (2013). α-ketoglutarate accumulation is not dependent on isocitrate dehydrogenase activity during tellurite detoxification in Escherichia coli. Biomed. Res. Int. (2013): 784190.
- Pradenas, G.A., Díaz-Vásquez, W.A., Pérez-Donoso, J.M., and Vásquez, C.C. (2013). Monounsaturated fatty acids are substrates for aldehyde generation in tellurite-exposed Escherichia coli. Biomed. Res. Int. 2013: 563756.
- Molina-Quiroz, R.C., Loyola, D.E., Muñoz-Villagrán, C.M., Quatrini, R., Vásquez, C.C., and Pérez-Donoso, J.M. (2013). DNA, cell wall and general oxidative damage underlie the tellurite/cefotaxime synergistic effect in Escherichia coli. PLoS ONE 8:e79499.
- Baeza, S., Vejar, N., Gulppi, M., Azócar, M., Melo, F., Monsalve, A., Pérez-Donoso, J.M., Vásquez, C.C., Pavez, J., Zagal, J.H., Zhou, X., Thompson, G.E., and Páez, M.A. (2013). New evidence on the role of catalase in Escherichia colimediated biocorrosion. Corrosion Sci. 67: 32-41.
- Reinoso, C.A., Auger, C., Appanna, V.D., and Vásquez, C.C. (2012). Telluriteexposed Escherichia coli exhibits increased intracellular α-ketoglutarate. Biochem. Biophys. Res. Commun. 421: 721-726.
- Sandoval, J.M., Verrax, J., Vásquez, C.C., and BucCalderón, P. (2012). A comparative study of tellurite in normal and cancer cells. Molec. Cell Toxicol. 8:327-334.
- Monrás J.P., Díaz V., Bravo D., Montes R.A., Chasteen T.G., Osorio-Román I.O., Vásquez C.C., and Pérez-Donoso J.M.(2012). Enhanced glutathione content allows the in vivo synthesis of fluorescent CdTe nanoparticles by Escherichia coli. PLoS ONE 7: e48657.
- Montes, R.A., Pradenas, G.A., Pérez-Donoso, J.M., Vásquez, C.C., and Chasteen, T. (2012). The acute bacterial toxicity of the selenocyanate anion and the bioprocessing of selenium by bacterial cells. Environ. Biotechnol. 8: 32-38.
- Elías, A.O., Abarca, M.J., Montes, R.A., Chasteen, T.G., Pérez-Donoso, J.M., and Vásquez, C.C. (2012). Tellurite enters Escherichia coli mainly through the PitAphosphate transporter. MicrobiologyOpen 1: 259-267.
- Molina, R.C., Muñoz-Villagrán, C.M., de la Torre, E., Tantaleán, J.C., Vásquez, C.C., and Pérez-Donoso, J.M. (2012). Enhancing the antibiotic antibacterial effect by sub lethal tellurite concentrations: tellurite and cefotaxime act synergistically in Escherichia coli. PLoS ONE 7: e35452.
- Pradenas, G.A., Paillavil, B.A., Reyes, S., Pérez-Donoso, J.M., and Vásquez, C.C. (2012). Reduction of the monounsaturated fatty acid content of Escherichia coli K-12 results in increased resistance to oxidative damage. Microbiology 158:1279-1283.
- Valdivia, M.A., Pérez-Donoso, J.M., and Vásquez, C.C. (2012). Effect of telluritemediated oxidative stress on the Escherichia coli glycolytic pathway Biometals 25: 451-458.
- Pérez-Donoso, J.M., Monrás, J.P., Bravo, D., Aguirre, A., Quest, A.F., Osorio-Román, I.O., Aroca, R., Chasteen, T.G., and Vásquez, C.C. (2012). Biomimetic, mild chemical synthesis of CdTe-GSH quantum dots with improved biocompatibility. PLoS ONE 7: e30741.
- Díaz, V., Ramírez-Maureira, M., Monrás, J.P., Vargas, J., Bravo, D., Osorio-Román, I.O., Vásquez,C.C., and Pérez-Donoso, J.M. (2012). Spectroscopic properties and biocompatibility studies of CdTe quantum dots capped with biological thiols. Science for Advanced Materials 4: 1-8.
Proyectos:
- FONDECYT # 1130362 (2013-2017).Tellurite-resistant Antarctic bacteria: unveiling new toxicantresistance mechanisms.
- CONICYT-MINCYT (Argentina) (2011-2013). Studies on the bioremediation process in heavy metal- and polycyclic aromatic hydrocarbon-contaminated soils (PAH). Interchange Project of the International Cooperation Program
- FONDECYT # 1090097 (2009-2012). Effects of potassium tellurite (K2TeO3) on the central metabolic pathways of Escherichia coli.