Academico Depto Ciencia Ambiente

Email: 
gloria.cardenas@usach.cl
Teléfono: 
227 181 137
Sitio web: 
Página Académica

Abstract

Our research is focused on the application of quantum chemistry to characterize the molecular and electronic structures, predict the chemical reactivity, and the photophysical and charge transport properties. The main research lines are applied to free and metal porphyrins, expanded porphyrins, phthalocyanines, organic dyes, nanocarbon materials (graphene, fullerene), and semiconductors (TiO2, SnO2). These correspond to (a) Molecular optoelectronic for solar cells, (b) Molecular electronic devices with single molecular junctions, (c) Mechanisms of dye photodegradation and Photodegradation of emerging contaminants in wastewater treatment, (d) Rational design of conductive metal-organic frameworks.
Línea(s) de investigación: 
Química Teórica Cuántica.
Jerarquía: 
Titular
Grados académicos /educación: 
Profesor de Química y Ciencias Naturales, Universidad Metropolitana de la Educación, Santiago, Chile, Marzo de 1987.
Magister en Ciencias Químicas, Facultad de Ciencias, Universidad de Chile, Santiago, Marzo de 1993.
Doctor en Ciencias con mención en Química, Facultad de Ciencias, Universidad de Chile, Santiago, Chile, Noviembre de 1996.
Publicaciones: 
  1. “Doping Effects in the Charge Transport of Graphene-Porphyrins”, Gloria Cárdenas-Jirón, Yanara Figueroa, Narendra Kumar, Jorge M. Seminario, Journal of Physical Chemistry C, (2015) accepted with revision. ISI
  2. “Tautomerization Mechanism and Spectral Properties of Porphyrin-Glucose Complexes as Models of Antibacterial Material”, M. Isabel Menéndez, Ramón López, Mauricio Yañez, Gloria Cárdenas-Jirón, submitted to Theoretical Chemistry Accounts, (2015) accepted with revision. ISI
  3. “Understanding the hydrolysis mechanism of ethyl acetate catalyzed by an aqueous molybdocene: A computational chemistry investigation”, Elkin Tílvez, Gloria I. Cárdenas-Jirón, María I. Menéndez, Ramón López, Inorganic Chemistry, 54 (2015) 1223-1231. ISI
  4. "Functionalized Graphene and Cobalt Phthalocyanine based Materials with Potential Use for Electrical Conduction", Gloria I. Cárdenas-Jirón, Paola León-Plata, Jorge M. Seminario, in “Design and Applications of Nanomaterials for Sensors” J.M. Seminario (Ed.) in Series: Challenges and Advances in Computational Chemistry and Physics, Vol. 16, (2014) pp. 185-215, ISBN 978-94-017-8847-2, Springer Dordrecht Heidelberg London New York.
  5. “Theoretical Assessment of the Photosensitization Mechanisms of Porphyrin-Ruthenium(II) Complexes for the Formation of Reactive Oxygen Species”, Laura E. Coitiño, Andy Mella, Gloria I. Cárdenas-Jirón, Journal of Photochemistry and Photobiology A: Chemistry, 294 (2014) 68-74. ISI
  6. “Electron Transport Properties through Graphene Oxide-Cobalt Phthalocyanine Complexes”, Gloria I. Cárdenas-Jirón, Paola León-Plata, Diego Cortes-Arriagada, Jorge M. Seminario, J. Phys. Chem. C, 117 (2013) 23664−23675. ISI
  7. “Assessment of the Photosensitization Properties of Cationic Porphyrins in Interaction with DNA Nucleotide Pair”, Gloria I. Cárdenas-Jirón, Luis Cortez, Journal of Molecular Modeling, 19 (2013) 2913-2924. ISI
  8. “A Three-Layer ONIOM Model for the Outside Binding of Cationic Porphyrins and Nucleotide Pair DNA”, Gloria I. Cárdenas-Jirón, Luis Cortez-Santibañez, Journal of Molecular Modeling, 19 (2013) 811-824. ISI
  9. “Nitric Oxide Oxidation by Substituted Nickel Phthalocyanines: A Theoretical Viewpoint”, Gloria I. Cárdenas-Jirón, Cristhy Gonzalez, Julie Benavides, J. Phys. Chem. C, 116 (2012) 16979−16984. ISI
  10. “Theoretical Study on the Electronic Excitations of a Porphyrin-Polypyridyl Ruthenium(II) Photosensitizer”, Gloria I. Cárdenas-Jirón, Cristina Barboza, Maria Isabel Menéndez, Ramón López, J. Phys. Chem. A,115 (2011) 11988–11997. ISI
  11. “Electrical Characteristics of Cobalt Phthalocyanine Complexes Adsorbed on Graphene”, Gloria I. Cárdenas-Jirón, Paola Leon-Plata, Diego Cortes-Arriagada, Jorge M. Seminario, J. Phys. Chem. C, 115 (2011) 16052-16062. ISI
  12. “A Through Space Charge Transfer Mechanism for Explaining the 2-Chlorophenol Oxidation on a Tetrasulphonated Nickel(III) Phthalocyanine”. Diego Cortés-Arriagada, Gloria I. Cárdenas-Jirón. Comput. Theor. Chem., 963 (2011) 161-167. ISI
  13. “Vibrational spectroscopy and density functional theory calculations of poly-D-mannuronic acid and heteropolymeric fractions from sodium alginate”. Gloria Cárdenas-Jirón, David Leal, Betty Matsuhiro, Igor O. Osorio-Román, J. Raman Spectrosc., 42 (2011) 870-878. ISI
  14. “Quantitative Structure Property Relationships To Evaluate the Photosensitizing Capability in Porphyrins and Chlorins”. Gloria I. Cárdenas-Jirón, Mireya Santander-Nelli, Ramón López, Maria Isabel Menéndez, Int. J. Quantum Chem., special issue by Prof. Sylvio Canuto, 111 (2011) 1570-1582. ISI
  15. “Flow-Induced -Hairpin Folding of the Glycoprotein Iba -Switch”. Xueqing Zou, Yanxin Liu, Zhongzhou Chen, Gloria Inés Cárdenas-Jirón, Klaus Schulten, Biophys. J., 99 (2010) 1182-1191. ISI
  16. "A Theoretical Investigation on the Spectroscopic Properties and Photosensitizing Capability of 5, 10, 15, 20-tetraphenylsapphyrin and 5, 10, 15, 20-tetraphenyl-26,28-deheterosapphyrins with two O, S, or Se Atoms". Ramón López, M. Isabel Menéndez, Mireya Santander, Gloria I. Cárdenas-Jirón, Theor. Chem. Acc., 127 (2010) 475–484. ISI
  17. "A Computational Study on the Stability-Aromaticity Correlation of Triply N-Confused Porphyrins". Violeta Yeguas, Gloria Inés Cárdenas-Jirón, María Isabel Menéndez, Ramón López, J. Math. Chem., 48 (2010) 137-144. ISI
  18. “Synthesis and Reactivity of 5-tetramethylcyclopentadienyl-propenyl rhenium Complexes: Molecular Structure of [(5:2-C5Me4CH2CH=CH2)Re(CO)2]”. Fernando Godoy, Alejandra Gómez, Gloria Cárdenas-Jirón, A. Hugo Klahn, Fernando J. Lahoz, J. Organomet. Chem., 695 (2010) 346-351. ISI
  19. "Inhibitory Effect of Aromatic Geranyl Derivatives isolated from Heliotropium filifolium on Infectious Pancreatic Necrosis Virus Replication". Brenda Modak, Ana María Sandino, Loredana Arata, Gloria Cárdenas-Jirón, René Torres, Veterinary Microbiology, 141 (2010) 53-58. ISI
Proyectos: 
  • FONDECYT N°1131002 – CONICYT. Theoretical Assessment of the Photosensitization of Porphyrins Anchored on Titanium Dioxide and Organic Supports, Investigadora responsable, 2013 - 2016.
  • Proyecto Inserción de Capital Humano Avanzado en la Academia Nº 79100010. Fortalecimiento de las áreas de química orgánica y de polímeros en la docencia e investigación, Investigadora responsable, 2011 - 2013.
Email: 
cristhian.berrios@usach.cl
Teléfono: 
27 181 000
Sitio web: 
http://www.experts.scival.com/UdeSantiago/expert.asp?n=CRISTHIAN%20E%20BERRIOS%2…

Abstract

En el área de electroquímica trabajo en la preparación y uso de electrodos  modificados (carbono vítreo, ITO, titanio, electrodos metálicos, entre otros) con catalizadores para la degradación de compuestos orgánicos contaminantes. Entre los compuestos contaminantes ya estudiados se encuentran clorofenoles y antibióticos. Actualmente se está trabajando con dióxido de titanio como catalizador sobre una superficie electródica, también en el área de la fotoquímica en una suspensión, o usando ambas técnicas en conjunto a través de la electroquímica asistida por fotoquímica.

El utilizar dióxido de titanio no sólo permitir trabajar en el área de degradación de compuestos contaminantes, sino que también en la obtención de energía a través de celdas fotovoltáicas. Este es un tema interesante debido a los actuales problemas energéticos.

Línea(s) de investigación: 
Electrocatálisis, degradación de compuestos contaminantes, electrodos modificados.
Jerarquía: 
Asistente
Grados académicos /educación: 
Químico, Universidad de Santiago de Chile.
Doctor en Química, Universidad de Santiago de Chile
Publicaciones: 
  1. M.S. Ureta-Zañartu; C. Berríos; J. Pavez; C. Gutierrez; J.H. Zagal. "Electrooxidation of chloro-phenols catalyzed by electrodes modified with Ni(II)tetrasulfophthalocyanine". En "Energy and Electrochemical Processes for a Cleaner Environment". E.W. Brooman, C.M. Doyle and C. Comninellis eds. The Electrochemical Society Symposium Series" PV 2001-23, (2001) 448–460.
  2. M. S. Ureta-Zañartu; P. Bustos; C. Berríos; M. C. Diez; M. L. Mora; C. Gutiérrez. “Electrooxidation of 2,4-dichlorophenol and other polychlorinated phenols at a glassy carbon electrode”. Electrochim. Acta, 47 (2002) 2399–2406. ISI IF:3,642
  3. M. S. Ureta-Zañartu; M. L. Mora; M. C. Diez; C. Berríos; J. Ojeda; C. Gutiérrez. “Chlorophenol electrooxidation on iron oxide-covered aluminosilicates deposited on glassy carbon”. J. Appl. Electrochem., 32 (2002) 1211–1218. ISI IF: 1,494
  4. M. S. Ureta-Zañartu; C. Berríos; J. Pavez; J. Zagal; C. Gutiérrez; J. Marco. “Electrooxidation of 2-chlorophenol on polyNiTSPc-modified glassy carbon electrodes” J. Electroanal. Chem., 553 (2003) 147–156. ISI IF: 2,732
  5. M. S. Ureta-Zañartu, A. Alarcón, C. Berríos, G. I. Cárdenas-Jirón, J. Zagal, C. Gutiérrez. “Electropreparation and characterization of polyNiTSPc films. An EQCM study”. J. Electroanal. Chem., 580 (2005) 94–104. ISI IF: 2,732
  6. C. Berríos; G. I. Cárdenas-Jirón; J. F. Marco; C. Gutiérrez; M. S. Ureta-Zañartu. “Theoretical and spectroscopy study of Ni(II)-porphyrin derivatives”. J. Phys. Chem. A, 111 (2007) 2706–2714. ISI IF: 2,732
  7. C. Berríos; M. S. Ureta-Zañartu; C. Gutiérrez. “Impedance study of electropolimerized films of polyNi(II)-macrocycles”. Electrochim. Acta, 53 (2007) 792 – 802. ISI IF: 3,642
  8. C. Berríos; R. Arce; M.C. Rezende; M.S. Ureta-Zañartu; C. Gutiérrez. “Electrooxidation of chlorophenols at a glassy carbon electrode in a pH 11 buffer”. Electrochim. Acta, 53 (2008) 2768–2775. ISI IF: 3,642
  9. Gloria I. Cárdenas-Jirón; Cristhian Berríos. “Theoretical evidence of the Ni(III) participation in the chlorophenol oxidation on tetrasulphonated nickel phthalocyanine”.  Int. J. Quant. Chem., 108 (2008) 2586 – 2594. ISI IF: 1,302
  10. Cristhian Berríos; José F. Marco; Claudio Gutiérrez; María Soledad Ureta-Zañartu. “Study by XPS and UV-visible and DRIFT spectroscopies of electropolymerized films of substituted Ni(II) phenylporphyrins and phthalocyanines” J. Phys. Chem. B, 112 (2008) 12644 – 12649. ISI IF: 3,603
  11. Cristhian Berríos; José F. Marco; Claudio Gutiérrez; María Soledad Ureta-Zañartu. “Electro-oxidation of chlorophenols at glassy carbón electrodes modified with polyNi(II)complexes”. Electrochim. Acta, 54 (2009) 6417 – 6425. ISI IF: 3,642
  12. Luis Cortez; Cristhian Berríos; Mauricio Yañez; Gloria I. Cárdenas-Jirón. “Theoretical study of the binding nature of glassy carbón with nickel(II) phthalocyanine complexes”. Chem. Phys., 365 (2009) 164 – 169. ISI IF: 2,017
  13. María Soledad Ureta-Zañartu; Thaís González; Francisco Fernández; Daniela Báez; Cristhian Berríos; Claudio Gutiérrez. “Electro-Oxidation of Benzyl and Aliphatic Alcohols on polyNiTSPc- and Ni(OH)2-Modified Glassy-Carbon and Gold Electrodes”.  Int. J. Electrochem. Sci., 7 (2012) 8794 – 8812. ISI IF: 3,729
  14. María Soledad Ureta-Zañartu, Cristhian Berríos, Thaís González, Francisco Fernández, Daniela Báez, Ricardo Salazar, Claudio Gutiérrez.  “Electrocatalytic Oxidation of Alcohols at Gold Electrodes in Alkaline Media”. Int. J. Electrochem. Sci., 7 (2012) 8905 – 8928. ISI IF: 3,729
Proyectos: 
  1. 2009, FONDECYT N°11090336, Investigador responsable. “Electrochemically Assisted Photocatalysis Degradation of Organics Contaminant in Water over Modified Electrode with TiO2”. Oct 2009 – sept2012. Investigador responsable

     
  2. 2008, Bicentenario PDA-03 Inserción en la Academia, CONICYT–USACH, Post-doctorado. “Degradación Electroquímica y Fotoquímica de Fármacos Contaminantes en Aguas sobre Electrodos Modificados con TiO2”. Nov. 2008 – Nov. 2011.
Otras actividades relevantes: 

Número de tesis dirigidas en los últimos 10 años: 

Magister:                   En desarrollo:             01

Email: 
alexis.aspee@usach.cl
Teléfono: 
27 181 133

Abstract

The extent of the oxidative damage induced by reactive oxygen species (ROS) in biological systems depends on a variety of factors that include the location of the target molecule with respect to the site of ROS formation, the reaction's rate constant, and the presence of antioxidants capable of ROS scavenging and/or repairing the initial damaged molecule. The complexity of these processes requires the development of new tools and strategies to pinpoint the free radical processes affecting a biological system. During the last few years our group has focused its research on developing new strategies to study free radical processes and mechanisms involved in amino acid and protein oxidation, such as spontaneous weak level chemiluminescence. Recently, we developed and applied nitroxide pre-fluorescent probes to monitor free radical formation in a wide variety of chemical systems, including zeolites, polymer films, and proteins. Furthermore, the use of these probes was extended to evaluate polyphenolic antioxidants in hydrogen and/or electron transfer-based reactions towards nitroxides, both in homogeneous and in microheterogeneous systems. These methodologies have allowed us to understand better antioxidant and free radical oxidation mechanisms in complex systems in concomitance with the use of time resolve techniques to monitor transient and free radical formation photoinduced by laser excitation of molecular probes and their reaction with proteins, amino acids, and also nitroxide and phenolic antioxidants.

Líneas de investigación

Durante los últimos años, nuestro grupo ha centrado su investigación en el desarrollo de nuevas estrategias para estudiar los procesos y mecanismos de radicales libres implicados en la oxidación de aminoácidos y proteínas, como la quimioluminiscencia espontánea de nivel débil. Recientemente, desarrollamos y aplicamos sondas pre-fluorescentes de nitróxido para monitorear la formación de radicales libres en una amplia variedad de sistemas químicos, incluidas zeolitas, películas poliméricas y proteínas. Además, el uso de estas sondas se amplió para evaluar antioxidantes polifenólicos en reacciones basadas en transferencia de hidrógeno y / o electrones hacia nitróxidos, tanto en sistemas homogéneos como microheterogéneos. Estas metodologías nos han permitido comprender mejor los mecanismos de oxidación de radicales libres y antioxidantes en sistemas complejos en concomitancia con el uso de técnicas de resolución temporal para monitorear la formación de radicales libres y transitorios fotoinducidos por excitación láser de sondas moleculares y su reacción con proteínas, aminoácidos y también nitróxido y antioxidantes fenólicos.

 

Jerarquía: 
Asociado
Grados académicos /educación: 
Químico, Universidad de Santiago de Chile, 1994
Doctor en Química, Universidad de Santiago de Chile, 2000 Postdoctorado: University of Ottawa, Canadá, 2001-2003
Publicaciones: 
  • L. Scarpetta-Pizo, R. Venegas, P. Barrías, K. Muñoz-Becerra, N. Vilches-Labbé, F. Mura, A. M. Méndez-Torres, R. Ramírez-Tagle, A. Toro-Labbé, S. Hevia, J. H. Zagal, R. Oñate, A. Aspée, I. Ponce, Electron Spin-Dependent Electrocatalysis for the Oxygen Reduction Reaction in a Chiro-Self-Assembled Iron Phthalocyanine Device, Angew. Chem. Int. Ed. 2023, 62, e202315146.
  • Zúñiga-Núñez, D., Mura, F., Mariño-Ocampo, N., Briones-Rebolledo, P., Poblete, H., Mallet, J-M., Fuentealba, D., Aspée, A. Time-resolved fluorescence and anisotropy-sensitive 1,2-dimyristoyl-snglycero-3-(7-aminocoumarin) phosphoetanolamide probe for studying membrane lipid domains, Dyes and Pigments, 2023, 111368, https://doi.org/10.1016/j.dyepig.2023.111368.
  • Orellana-Maldonado, I., Aspée, A., Barrias, P., Santana, P. A., Tirapegui, C., Photoswitching studies of new photochromic ionic liquids studied in real time by in situ irradiation, New J. Chem., 2022,46, 12825-12835, https://doi-org.ezproxy.usach.cl/10.1039/D2NJ01194H.
  • Cortés-Quezada, M., Parada, A.M., Videla, X., Valdés, J. A., Gonzalez-Catrilelbún, S., Aspée, A., Nario, A., Rivas-Aravena, A., Labelling fish diets with 15 N -Leucine for monitoring feed consumption and bio-distribution in Atlantic salmon, Vet Med Sci. 2022;1 8. DOI: 10.1002/vms3.730.
  • Bridi R, Gonzalez A, Bordeu E, Lopez-Alarcon C, Aspee A, Diethelm B, Lissi E, Parpinello GP, Versari A. Monitoring peroxides generation during model wine fermentation by FOX-1 assay. Food Chem. 175, 25-28 (2015) ISI 2014: 3.391. DOI: 10.1016/j.foodchem.2014.11.126.
  • E. Dorta, E. Fuentes-Lemus, A. Aspee, E. Atala, H. Speisky, R. Bridi, E. Lissi, C. Lopez- Alarcon, The ORAC (oxygen radical absorbance capacity) index does not reflect the capacity of antioxidants to trap peroxyl radicals, RSC Adv. 5, 39899-39902 (2015) ISI 2014: 3.84. DOI: 10.1039/C5RA01645B
  • M. Liras, S. Simoncelli, A. Rivas-Aravena, O. Garcia, J. C. Scaiano, E. I. Alarcon, A. Aspee, Nitroxide amide-BODIPY probe behavior in fibroblasts analyzed by advanced fluorescence microscopy, Organic & Biomolecular Chemistry, (2016), 14, 4023 - 4026. ISI 2014: 3.562. DOI: 10.1039/C6OB00533K
  • E. Fuentes-Lemus, E. Dorta, E. Escobar, A. Aspee, E. Pino, M. L. Abasq, H. Speisky, E. Silva, E. Lissi, M. J. Davies, C. Lopez-Alarcon, Oxidation of free, peptide and protein tryptophan residues mediated by AAPH-derived free radicals: role of alkoxyl and peroxyl radicals, RSC Adv.(2016) 6, 57948. ISI 2014: 3.84. 10.1039/C6RA12859A
  • J. Benavides, P. Barrias, N. Piro, A. Arenas, A. Orrego, E. Pino, L. Villegas, E. Dorta, A. Aspee⁎, C. Lopez-Alarcon⁎. Reaction of tetracycline with biologically relevant chloramines, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, (2017), 178, 171–180. ISI 2014: 2.353. DOI: 10.1016/j.biopha.2017.03.082
  • E. Dorta, A. Aspee, E. Pino, L. Gonzalez, E. Lissi, C. Lopez-Alarcon, Controversial alkoxyl and peroxyl radical scavenging activity of the tryptophan metabolite 3-hydroxy-anthranilic acid, Biomedicine & Pharmacotherapy, (2017), 90, 332-338. ISI 2014: 2.023
  • A. Aspee, C. Aliaga, L. D. Zuniga-Nunez, J. Godoy, E. Pino, G. Cardenas-Jiron, C. Lopez- Alarcon, JC Scaiano, EI Alarcon, Reaction Kinetics of Phenolic Antioxidants Towards Photo- Induced Pyranine Free Radicals in Biological Models, J. Phys. Chem. B. (2017), 121, 6331-6340. ISI 2014: 3.302. DOI: 10.1021/acs.jpcb.7b02779
  • Daniel Zuniga-Nunez, Pablo Barrias, Gloria Cardenas-Jiron, M. Soledad Ureta-Zanartu, Camilo Lopez-Alarcon, F. Eduardo Moran Vieyra, Claudio D. Borsarelli, Emilio I. Alarcon, Alexis Aspee*, Atypical antioxidant activity of non-phenolic amino-coumarins, RSC Adv. (2018), 8, 1927-1933. ISI 2014: 3.84 DOI: 10.1039/C7RA12000A
  • Fuentes-Lemus E, Silva E, Barrias P, Aspee A, Escobar E, Lorentzen LG, Carroll L, Leinisch F, Davies MJ, Lopez-Alarcon C. Aggregation of α- and β- caseins induced by peroxyl radicals involves secondary reactions of carbonyl compounds as well as di-tyrosine and di-tryptophan formation. Free Radic Biol Med. (2018), 124, 176-188. ISI 2014: 5.784 doi: 10.1016/j.freeradbiomed.2018.06.005.
  • Daniel Zuniga-Nunez, Ricardo A. Zamora, Pablo Barrias, Cristian Tirapegui, Horacio Poblete, Gloria Cardenas-Jiron, Emilio I. Alarcon, Alexis Aspee. Theoretical rationalisation of the photophysics of a TICT excited state of cinnamoyl–coumarin derivatives in homogeneous and biological membrane models, Phys Chem Chem Phys. (2018) Nov 7;20(43):27621-27629. doi: 10.1039/c8cp04963g.
  • E. Silva, P. Barrias, E. Fuentes-Lemus, C.Tirapegui, A. Aspee, L. Carroll, M. J. Davies, C. Lopez-Alarcon, Riboflavin-induced Type 1 photo-oxidation of tryptophan using a high intensity 365‚ nm light emitting diode, Free Radical Biology and Medicine, (2019), 131, 133-143. https://doi.org/10.1016/j.freeradbiomed.2018.11.026
  • Francisco Mura, Daniel Zuniga-Nunez, Jean-Maurice Mallet, Solange Lavielle, Pascal Matton, Pablo Barrias, Denis Fuentealba, Alexis Aspee, A microenvironment-sensitive coumarinlabeled peptide for the assessment of lipid-peptide interactions, Dyes and Pigments (2020), 176, 108234
  • Zamora RA, Fuentes-Lemus E, Barrias P, Herrera-Morande A, Mura F, Guixe V, Castro- Fernandez V, Rojas T, Lopez-Alarcon C, Aguirre P, Rivas-Aravena A, Aspee A., Free 11 radicals derived from γ-radiolysis of water and AAPH thermolysis mediate oxidative crosslinking of eGFP involving Tyr-Tyr and Tyr-Cys bonds: the fluorescence of the protein is conserved only towards peroxyl radicals. Free Radic Biol Med. (2020) Feb 17;150:40-52
  • Zúniga-Nunez, D, Mura, F., Zamora, R. A., Poblete, H., Fuentealba, D., Aspee, A. Cinnamoyl– coumarin hybrid derivatives with remarkable fluorescent molecular-rotor properties in mixtures of DPPC:DOPC LUVs, Dyes and Pigments 178 (2020) 108356.
  • Castro, J., Fernandez, F., Olivares, F., Berrios, C., Garrido-Ramirez, E., Blanco, E., Escalona, N., Aspee, A., Barrias, P., Ureta-Zanart, M. S. Electrodes based on zeolites modified with cobalt and/or molybdenum for pesticide degradation: part II—2,4,6-trichlorophenol degradation, J. Solid State Electrochem. (2020) https://doi.org/10.1007/s10008-020-04590-6
  • Reyes, J.S., Fuentes-Lemus, E., Aspee, A., Davies, M. J., Monasterio, O., Lopez-Alarcon, C. M. jannaschii FtsZ, a key protein in bacterial cell division, is inactivated by peroxyl radicalmediated methionine oxidation, Free Radic Biol Med. 166 (2021) 53-66. doi: 10.1016/j.freeradbiomed.2021.02.003.

 

Proyectos: 
  • 2021-2025 FONDECYT 1211351 (Co-investigador) Interplay between Molecular Electronics and Electrocatalysis: Electrocatalytic Self-assembled systems as "supramolecular nano-devices" for applications in clean energy conversion.
  • 2022-2026 FONDECYT 1220459 (Co-investigador) Dimers and Heterodimers of Tryptophan and Tyrosine as Biomarkers of Protein Oxidation: Analytical Approaches for their Quantification in Isolated Proteins, Cell Extracts and C. Elegans Worms
  • 2023-2026 FONDECYT 1231468 (Investigador Principal) Evaluation of conformational dynamic aspects on the oxidation of antimicrobial-inspired peptides in phospholipid membranes by fast photoinduced free radical generation
  • 2015 FONDEQUIP EQM 150084 GC MS MS Plataforma de Cromatografía de Gases acoplada a espectrometría de Masa/Masa para el desarrollo de investigación multidisciplinar en la Universidad de Santiago de Chile en el estudio de compuestos volátiles en problemáticas transversales.
  • 2014-2018 FONDECYT-Chile 1140240 (Principal Investigador) Photoinduced free radicals and excited triplet states formation in organised biological mimetic systems.
  • 2014-2018 FONDECYT-Chile 1141142 (Co-investigador) Role of tryptophan residues in the aggregation and fragmentation of peptides and proteins induced by peroxyl and carbón centered radicals.
  • 2013 FONDEQUIP EQM 120065 UHPLC MSMS. Mejoramiento de equipamiento para detección de intermediarios y productos de reacción para los grupos de investigación de Cinética Química y Electroquímica de la Universidad de Santiago de Chile
  • 2013-2015 FONDECYT-3130697 Postdoctorado /Dr. Christian Aliaga (Patrocinante) Photochemistry of organic molecules in homogeneous and constrained media
  • 2017-2019 FONDECYT-3170590 Postdoctorado /Dr. Francisco Mura (Patrocinante) Nueva perspectiva de sondas duales nitróxido-fluoróforo en péptidos: estudio de su interacción con bicapas lipídicas.
  • 2017-2021 FONDECYT-1170842 (Co-investigador) Enhancement of endothelium signaling by dietary polyphenols and potassium supplements in control and STZdiabetic rats.
  • 2018-2022 FONDECYT-1180642 (Co-investigador) Oxidative modifications induced by carbonate radical, nitrogen dioxide, and peroxyl radicals on two enzymes of the pentose phosphate pathway: consequences on NADPH release and reduced glutathione recycling.
  • 2019-2023 FONDECYT-1190881 (Principal Investigador) Electron transfer processes in peptides induced by free radicals: Influence of the amino acid sequence, peptide conformation and microenvironment.
Email: 
iriux.almodovar@usach.cl
Teléfono: 
27 181 161
Sitio web: 
http://www.experts.scival.com/UdeSantiago/expert.asp?n=IRIUX%20ALMODOVAR%20FAJAR…

Abstract

Developing of green synthetic strategies to obtain compounds with interesting pharmacological properties.

Línea(s) de investigación: 
Síntesis Orgánica - Mecanismos de reacción, Química Verde
Jerarquía: 
Asistente
Grados académicos /educación: 
Químico, Universidad de La Habana, 1996
Doctor en Química, Universidad de Chile, 2006.
Publicaciones: 

  • Jorge Ariel Saavedra-Olavarría*, Patricio Hermosilla-Ibáñez, Edwin G. Pérez, and Iriux Almodóvar (2022), “Fast Heating-Assisted One-pot Copper-Catalysed Sulfonylation and Sulfochlorination of Styrenes” Eur. J. Org. Chem. 2022, e202101526. (IF=3,021)

  • Arteaga, Gean C.; Saavedra-Olavarria, Jorge; Almendras, Sebastian; Hermosilla-Ibanez, Patricio; Almodovar, Iriux; Perez, Edwin G.* Copper-catalyzed intermolecular aminochlorination of alkenes. Tetrahedron Letters, 2018, 59, (12),191-193 (IF=2.415)

  • Saavedra-Olavarria, Jorge; Madrid-Rojas, Matias; Almodovar, Iriux; Hermosilla-Ibanez, Patricio; Perez, Edwin G*. Synthesis of beta-alkoxy-N-protected phenethylamines via one-pot copper-catalyzed aziridination and ring opening. RSC Advances, 2018, 8, (49), 27919-27923 (IF=3.390)

  • Almodovar, Iriux*; Caroli Rezende, Marcos; Cassels, Bruce K.; Garcia-Arriagada, Macarena, Theoretical insights into the regioselectivity of a Pictet-Spengler reaction: Transition state structures leading to salsolinol and isosalsolinol, JOURNAL OF PHYSICAL ORGANIC CHEMISTRY, 2017, 30 (8) (IF=2.391)

  • C. Aliaga, I. Almodovar and M. C. Rezende, A single theoretical descriptor for the bond-dissociation energy of substituted phenols, J. Mol. Model., 21 (2015), 2572. Impact Factor=1.867I.

  • M. C. Rezende, I. Ponce, R. Oñate, I. Almodovar, C. Aliaga. Change of mechanism with a change of substituents for a Zincke reaction. Tetrahedron Letters 55 (2014) 3097. Impact Factor= 2.397.

  • P. Abarca, P. Silva, I. Almodovar, M. C. Rezende* Preparation and properties of perichromic dye: an undergraduate laboratory, Quim. Nova, 37(4) (2014) 745. Impact Factor =0.737.

  • I. Almodovar*, T. Delgado-Castro, G. Zapata-Torres, M. C Rezende, R. Araya-Maturana, Factors affecting the competitive reduction of 8,8-dimethylnaphthalene-1,4,5(8H)-trione in a Diels-Alder cycloaddition with hydroxysulfinyldienes. J.Iran.Chem.Soc., (2014), Volume 11, Issue 4, 1021-1026 . Impact Factor= 1.467.

  • I. Almodovar*, W. Cardona, T. Delgado-Castro, G. Zapata-Torres, M. C. Rezende, R. Araya-Maturana, M. C. Maestro, J. L. García Ruano, Remote regio- and stereocontrol by the sulfinyl group. Diels-Alder reaction of sulfinyl dienols and 8,8-dimethylnaphthalene-1,4,5(8H)-trione. Tetrahedron: Asymmetry, 24 (2013) 56. Impact Factor= 2.652.

  • M. A. Juricic*, P. A. Berríos-Cárcamo, M. L. Acevedo, Y. Israel, I. Almodovar, B. K. Cassels, Salsolinol and isosalsolinol: condensation products of acetaldehyde and dopamine.Separation of their enantiomers in the presence of a large excess of dopamine. Journal of pharmaceutical and biomedical analysis, 63 (2012) 170. Impact Factor=2.723.

  • M. C. Rezende*, I. Almodovar, Substituent electrophilicities in the NMR spectra of barbituric Derivatives, Magnetic Resonance in Chemistry, 50 (2012) 266. IF= 1,247.

  • H. Pessoa-Mahana*, I. M. Cuevas, D. C. Pessoa-Mahana, R. Araya-Maturana, I. Almodovar and C. A. Saitz-Barrá, Synthesis of 1-Benzyl-3-[4-(Aryl-1-Piperazinyl) Carbonyl]-1h-Indoles: Novel Ligands With Potential D4 Dopaminergic Activity. Journal of Chilean Chemical Society, 56, 4 (2011) 866. Impact Factor= 0.448.

  • I. Almodovar*, O. Ramírez-Rodríguez, A. Barriga, M. C. Rezende, R. Araya-Maturana, Electrospray ionization mass spectrometric fragmentation of hydroquinone derivatives. Rapid Commun. Mass Spectrom. 25 (2) (2011) 370. Impact Factor=2.846.

Capítulo de Libro:

Sandra Patricia Rojas Rojas , Iriux Almodovar, Ignacio Tapia, Nicolás Troncoso and David Leal,” “Promoción de habilidades de pensamiento científico y el diagrama heurístico en las actividades de laboratorio de Química Orgánica I. Experiencia en la formación de futuros profesores de química y biología.” Innovar y Transformar desde las Disciplinas: Experiencias claves en la Educación Superior en América Latina y El Caribe 2021-2022 https://doi.org/10.34720/zmdk-a274

Proyectos: 
No1211619 ,Co-investigadora,  (ANID 2021-2025)

No 018-2018, Investigadora Principal  (PID, VRA Marzo 2019- Agosto 2020)

No 012-2018, Co-investigadora  (PID, VRA, Marzo 2019- Agosto 2020)

No 1171391, Co-investigadora (FONDECYT 2017-2021)

021641AF, Investigadora responsable (DICYT 2016-2019)

Nº 11121270 (Iniciación).  Investigadora Principal. 2012 - 2015.

 
Nº 3100059 (Postdoctorado). Investigadora Principal. 2009 - 2012.

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