Clase abierta y gratuita: Fármacos II y el nuevo escenario para los medicamentos y dispositivos médicos
Matsuhiro Yamamoto Betty
Email:
bety.matsuhiro@usach.cl
Teléfono:
27 181 159
Abstract
Research is related to:
- Structural determination of polysaccharides by chemical and spectroscopic methods.
- Chemical modifications of polysaccharides. Synthesis of glycoconjugates.
- Carbohydrate derivatives as ligands in the formation of coordination compounds with metals.
Línea(s) de investigación:
Química de hidratos de carbono
Jerarquía:
Titular
Grados académicos /educación:
Licenciado en Química, Universidad de Buenos Aires, 1961
Doctor en Química, Universidad Buenos Aires, Argentina, 1964.
Publicaciones:
- L.E.Lillo, B. Matsuhiro*. Chemical modifications of 1®4-2-amino-2-deoxy-a-D-galactan. Carbohydr. Polym. 51, 317-325 (2003). IF: 3,987.
- J. Costamagna, L.E. Lillo, B. Matsuhiro*, M.D. Noseda, M. Villagrán. Ni(II) complexes with Schiff bases derived from aminosugars as ligands. Carbohydr. Res., 338, 1535-1542 (2003). IF: 2,386.
- C. Sáenz*, E. Sepúlveda, B. Matsuhiro. Opuntia spp. Mucilage’s: a functional component with industrial perspectives. J. Arid. Environm., 57, 275-290, 2004. IF: 2,135.
- N.P. Chandía, B. Matsuhiro*, E. Mejías, A. Moenne. Alginic acid in Lessonia vadosa: Partial hydrolysis and elicitor properties of the polymannuronic acid fraction. J. Appl. Phycol., 16, 127-133 (2004). IF: 2,411.
- P.J. Cáceres, J. Costamagna, A. Danil de Namor, B. Matsuhiro*. Lower rim p-tert-butylcalix[4]arene derivatives containing galactitol pendants. Complexation of 5,11,17,23-tetrakis-(1,1-dimethylethyl)-25,27-dihydroxy-26,28-Bis-2-N-(1-deoxy-D-galactityl)-aminoethoxycalix[4]arene with Pb(II) and F(-I). J. Chil. Chem. Soc., 49, 281-284 (2004).IF: 0,65.
- J. Zúñiga, L. Lillo, J. Shin, R.L. Machavarapu, T. Quiroga, M. Goycolea, B. Matsuhiro, L. Aron-Hott, H.P. Godfrey, F.C. Cabello*. Salmonella enterica serovar Typhi O:1,9,12 polysaccharide-protein conjugate as typhoid fever diagnostics., J. Clin. Microbiol., 43, 4545-4550 (2005). IF: 4,399.
- N.P. Chandía, B. Matsuhiro*, J.S. Ortiz, A. Mansilla. Carbohydrates from the sequential extraction of Lessonia vadosa (Phaeophyta). J. Chil. Chem. Soc., 50, 501-504 (2005). IF: 0,65.
- B. Matsuhiro*, A.F. Conte, E.B. Damonte, A.A. Kolender, M.C. Matulewicz, E.G. Mejías, C.A. Pujol, E.A. Zúñiga. Structural analysis and antiviral activity of a sulfated galactan from Schizymenia binderi (Gigartinales, Rhodophyta). Carbohydr. Res., 340, 2392-2402 (2005). IF: 2,386.
- B. Matsuhiro*, L.E. Lillo, C. Sáenz, C.C. Urzúa, O. Zárate. Chemical characterization of the mucilage from fruits of Opuntia ficus indica. Carbohydr. Polym., 63, 263-267 (2006). IF: 3,987.
- B. Matsuhiro*, L.C. Presle, C.Sáenz, C.C. Urzúa. Structural determination and chemical modification of the polysaccharide from seeds of Prosopis chilensis Mol. (Stuntz). J. Chil. Chem. Soc., 51, 809-813 (2006). IF: 0,65.
- E.A. Zúñiga, B. Matsuhiro*, E. Mejías. Preparation of a low molecular weight fraction by free radical depolymerization of the sulfated galactan from Schizymenia binderi (Gigartinales, Rhodophyta) and its anticoagulant activity. Carbohydr. Polym., 66, 208-215 (2006). IF: 3,987.
- D. Laporte, J. Vera, N.P. Chandía, E.A. Zúñiga, B. Matsuhiro, A. Moenne*. Structurally-unrelated algal oligosaccharides differentially stimulate growth and defense against Tobacco Mosaic Virus in tobacco plants. J. Appl. Phycol., 19, 79-88 (2007). IF: 2,411.
- B. Matsuhiro*, S.E. Torres, J. Guerrero. Block structure in alginic acid from Lessonia vadosa (Laminariales, Phaeophyta). J. Chil. Chem. Soc., 52, 1095-1098 (2007). IF: 0,65
- D. Leal, B. Matsuhiro*, M. Rossi, F. Caruso. FT-IR spectra of alginic acid block fractions in three species of brown seaweeds. Carbohydr. Res., 343, 308-316 (2008). IF: 2,386
- N.P. Chandía, B. Matsuhiro*. Characterization of a fucoidan from Lessonia vadosa (Phaeophyta) and its anticoagulant and elicitor properties. Int. J. Biol. Macromol., 42, 235-240 (2008). IF: 2,45.
- F. Fuenzalida, P. Dreyse, D. Villagra, B. Matsuhiro, L. Mendoza, M.J. Aguirre, M. Isaacs*. Electrochemical reduction of SO2 on poly-Co-3-tetraaminophenylporphyrin glassy carbon modified electrode. J. Coord. Chem., 62, 130-140 (2009). IF: 1,547.
- P. Bravo, Y.Y. Chen, G. Ramirez, M.J. Canales, B. Matsuhiro, L. Mendoza, M. Isaacs, M. C. Arevalo, M.J. Aguirre*. Electrooxidation and determination of sulfite in ethanol-water solutions using poly-Cu(II)-tetrakis(X-tetraaminophenyl)-Porphyrin/glassy carbon modified electrodes. Collect. Czech.Chem. Commun., 74, 545-557 (2009). IF: 1,28.
- C. García, D.Villagra, F. Caruso, M. Rossi, B. Matsuhiro, L. Mendoza, M. J. Aguirre, M. Isaacs*. Synthesis, structure and electrochemical properties of the cationic complex tris-(imidazolidine-1,10-phenanthroline)iron(II). Inorg. Chem. Commun. 12, 392-395 (2009). IF: 1,901.
- M.J. Aguirre, M. Isaacs, B. Matsuhiro*, L. Mendoza, E.A. Zúñiga. Characterization of a neutral polysaccharide with antioxidant capacity from red wine. Carbohydr. Res., 344, 1095-1101 (2009). IF: 2,386.
- G. Ramírez, M.C. Goya, L. Mendoza, B. Matsuhiro, M. Isaacs, Y.Y. Chen, M.C. Arévalo, J. Henríquez, W. Cheuquepan, M.J. Aguirre*. Iron porphyrin-modified electrodes: influence of the method of modification on the stability and electroactivity in oxidation of sulfite or hydrogensulfite in ethanol–water solutions. J. Coord. Chem., 62, 2782-2791 (2009). IF: 1,547.
- B. Matsuhiro*, R. Torres, E.A. Zuniga, M.J. Aguirre, L. Mendoza, M. Isaacs. Determination of low molecular weight carbohydrates in Cabernet Sauvignon red wines. J. Chil. Chem. Soc., 54, 405-407 (2009). IF: 0,65.
- K. Calfumán, M.J. Aguirre, D. Villagra, C. Yañez, C. Arevalo, B. Matsuhiro, L. Mendoza, M. Isaacs*. Nafion/tetraruthenated porphyrins glassy carbon modified electrode: Characterization and voltammetric studies of sulfite oxidation in water-ethanol solutions., J. Solid. State Electrochem., 14, 1065-1072 (2010). IF: 2,131.
- M.J. Aguirre, Y.Y. Chen, M. Isaacs, B. Matsuhiro*, L. Mendoza, S. Torres. Electrochemical behaviour and antioxidant capacity of anthocyanins from Chilean red wine, grape and raspberry. Food Chem., 121, 44-48 (2010). IF: 4,268.
- K. Calfumán, M. García, M.J. Aguirre, B. Matsuhiro, L. Mendoza, M. Isaacs*. Electrochemical reduction of S(IV) compounds in water-ethanol solutions at nafion/tetraruthenated porphyrins glassy carbon modified electrodes. Electroanalysis, 22, 338-344 (2010). IF: 2,372.
- M. M. Campos-Vallette, N. P. Chandía, E. Clavijo, D. Leal, B. Matsuhiro*, I. O. Osorio-Román, S. Torres. Characterization of sodium alginate and its block fractions by Surface-Enhanced Raman Spectroscopy. J. Raman Spectros., 41, 758-763 (2010). IF: 3,087.
- W. Cheuquepán, D. Villagra, M.I. Azócar, G. Ramírez, Y.Y. Chen, B. Matsuhiro, L. Mendoza, M. Isaacs, M.J. Aguirre*. Effect of the number of substituents on the behavior of modified electrodes with cobalt porphyrins substituted with a different numbers of bis(methoxyphenyl) groups toward the oxidation of sulfite. J. Chil. Chem. Soc., 55, 253-256 (2010). IF: 0,65.
- I.O. Osorio-Román*, R.F. Aroca, J. Astudillo, B. Matsuhiro, C. Vásquez, J.M. Pérez. Characterization of bacteria using its O-antigen with surface enhanced Raman scattering. Analyst 135, 1997-2001 (2010). IF: 4,23.
- T. Barahona, N.P. Chandía, M. V. Encinas, B. Matsuhiro*, E. A. Zúñiga. Antioxidant capacity of sulfated polysaccharides from seaweeds. A kinetic approach., Food Hydrocolloids, 25, 529-535 (2011). IF: 3,46.
- G. Cárdenas-Jirón, D. Leal, B. Matsuhiro*, I.O. Osorio-Román. Vibrational spectroscopy and density functional theory calculations of poly-D-mannuronate and heteropolymeric fraction of sodium alginate. J. Raman Spectros. 42, 870-878 (2011). IF: 3,087.
- S. Torres, G. Ferraudi*, M.J. Aguirre, M. Isaacs, B. Matsuhiro, N.P. Chandía, L. Mendoza On the ligand to metal charge transfer photochemistry of the copper (II) complexes of quercetin and rutin. Helv. Chim. Acta, 94, 293-300 (2011). IF: 1,47.
- G. Ferraudi*, N.P. Chandía, B. Matsuhiro, S. Torres. Observations on the mechanisms of the thermal and photoinduced oxidation of D-mannitol and fucoidan by transition metal complexes and inorganic radicals. J. Coord. Chem., 64, 377-389 (2011). IF: 1,547.
- J. Vera, J. Castro, A. González, H. Barrientos, B. Matsuhiro, P. Arce, G. Zúñiga, A. Moenne*. Long-term protection against tobacco mosaic virus induced by the marine alga oligo-sulphated-galactan Poly-Ga in tobacco plants.. Mol. Plant Pathol. 12, 437-447 (2011). IF: 3,899.
- C. García, C. Domínguez, A. Aliaga, B. Matsuhiro, L. Mendoza, M.J. Aguirre, M. Isaacs*. Electrochemical properties of a conducting film derived from iron (II) tris-diaminepolypyridyl complex in the S (IV) oxoanions reduction. Electroanalysis, 23 (6), 1401-1409 (2011). IF: 2, 372.
- M.J. Aguirre, M. Isaacs, B. Matsuhiro*, L. Mendoza, L.S. Santos, S. Torres. Anthocyanin composition in aged Chilean Cabernet Sauvignon red wines. Food Chem., 129, 514-519 (2011). IF: 4,268.
- L. Mendoza*, B. Matsuhiro, M.J. Aguirre, M. Isaacs, G. Sotes, M. Cotoras, R. Melo Characterization of phenolic acids profile from Chilean red wines by high-performance liquid chromatography. J. Chil. Chem. Soc., 56, 688-691 (2011). IF: 0,65
- F. Caruso*, L. Mendoza, P. Castro, M. Cotoras, M. Aguirre, B. Matsuhiro, M. Isaacs, M. Rossi, A. Viglianti, R. Antonioletti. Antifungal activity of resveratrol against Botrytis cinerea is improved using 2-furyl derivatives. PLoS ONE, 6(10):e25421, doi:101371 (2011). IF: 4,09.
- T. Barahona, M. V. Encinas, A. Mansilla, B. Matsuhiro*, E. A. Zuñiga A sulfated galactan with antioxidant capacity from the green variant of tetrasporic Gigartina skottsbergii (Gigartinales, Rhodophyta). Carbohydr. Res., 347, 114-120 (2012). IF: 2,386.
- B. Matsuhiro*, I. Osorio-Román, R. Torres. Vibrational spectroscopy characterization and anticoagulant activity of a sulfated polysaccharide from sea cucumber Athyonidium chilensis. Carbohydr. Polym. 88, 959-965 (2012). IF: 3,987.
- P. Dreyse, D. Quezada, J. Honores, M.J. Aguirre, L. Mendoza, B. Matsuhiro, D. Villagra, M. Isaacs*. Determination of S(IV) oxoanions at poly-[Ru(5-NO2-phen)2Cl]tetrapyridilporphyrin glassy carbon modified electrode. Electroanalysis, 24, 1703-1708 (2012). IF: 2,372
Proyectos:
Investigador responsable
- “Polisacáridos sulfatados de algas: estructura química y propiedades biológicas”, FONDECYT 1010594 (2001-2004).
- “Polisacáridos solubles de algas del género Lessonia”, DICYT (2005-2006).
- “Diseño de un sensor electroquímico para sulfito y determinación electroquímica de la capacidad antioxidante de fenoles en vino. Programa Bicentenario de Ciencia y Tecnología. Proyecto Anillo ACT 24”, CONICYT-Banco Mundial (2006-2009).
- “Determinación estructural de polisacáridos sulfatados y estudio de algunas de sus propiedades biológicas”, DICYT (2009-2010).
- “Determinación estructural y modificación química de polisacáridos de algas”, DICYT (2011-2012).
Co-Investigador
- “Cultivo y biotecnología de Ahnfeltia plicata, nueva alternativa en la producción de ficocoloides para la Región de Magallanes". Proyecto FONDEF (2010-2013).
- “Formulación de nanofibras de quitosano contenedores de compuestos antioxidantes para su potencial uso en neuroprotección” Proyecto Fundación Copec-UC, Nº 8CO55” (2011-2013).
Otras actividades relevantes:
Número de tesis dirigidas en los últimos 10 años:
Magister: Dirigidas: 1 En desarrollo: 1
Doctorado: Dirigidas: 7 En desarrollo: 2
Otras publicaciones y patentes
- Alginic acids from Phaeophyta of Magellan Region (Chile). B. Matsuhiro*, D. Leal, A. Mansilla. Capítulo en libro "Alginates: Production, Types and Applications", M. Molina, A.J. Quiroga Eds., Nova Publishers, Nueva York (2012), pp. 217-234.
Patente en trámite
- “Fabricación de electrodos de carbón”, M.J. Aguirre, C. Arevalo, M. Isaacs, B. Matsuhiro, L. Mendoza, J. Romero.
Comité editorial revistas científicas
- Miembro del comité editorial de Journal of Chilean Chemical Society
Referee de revistas internacionales
- Carbohydrate Research, Carbohydrate Polymers, Food Chemistry, International Journal of Biological Macromolecules, Journal of Chilean Chemical Society, Journal of Agricultural and Food Chemistry, etc.
Revisor de proyectos
- FONDECYT
- CONICET, Argentina
- Universidades Nacionales
Participación en claustro de doctorados
Doctorado en Química, Facultad de Química y Biología, Usach.