Urzúa Moll Alejandro

Email: 
alejandro.urzua@usach.cl
Teléfono: 
27 181 154
Sitio web: 
http://www.experts.scival.com/UdeSantiago/expert.asp?n=ALEJANDRO%20URZUA%20MOLL&…
Abstract

In general, the investigation is focused on the isolation and structural determination of different families of secondary metabolites, and their biological properties determination.
The main research areas are: 
Investigation of the antimicrobial activity (both antifungal and antibacterial) of secondary metabolites, specially diterpenoids, monoterpenoids and flavonoids, through structural determination, activity evaluation, synthetic transformations, action mechanisms, physicochemical properties calculations, molecular modeling and structure-activity relations.
 Chemical Ecology, the study of origin, function and role of natural products that mediate inter and intra-specific interactions between organisms, and organisms interactions with abiotic elements in the ecosystem. Also, the repellent and insecticidal effect of certain essential oils from plants, the composition of volatiles that attract insects to host-plants, and the role of volatiles as pheromones.

Línea(s) de investigación: 
Química de Productos Naturales.
Jerarquía: 
Titular
Grados académicos /educación: 
Técnico Químico Industrial, Universidad Técnica del Estado.
Doctor en Ciencias con Mención Química, Universidad de Chile, 1983.
Publicaciones: 

1.- Urzúa A(*), Mendoza L, (2003) Antibacterial activity of fresh flowerheads of Chrysanthemum coronarium . Fitoterapia 74: 606-608. ISI IF=1,848

2.- Urzúa A(*), Torres R, Mendoza L, Delle Monache F, (2003) Antibacterial new clerodane diterpenes from the surface of Haplopappus foliosus.  Planta Med. 69: 675-677. ISI IF=2,369

3.- Urzúa A(*), (2004) Mono and sesquiterpenes in the trichome secreted exudate from Pseudognaphalium cheiranthifolium, P. heterotrichium, P.  vira-vira and P. robustum. Biochem. Syst. Ecol.  32: 215-218. ISI IF=1,110

4.- Urzúa A(*), Contreras R, Jara P, Avila F, Suazo M, (2004) Comparative chemical composition of the trichome secreted exudate and of the maxy coating from Haplopappus velutinus, H. illinitus, H. shumanni and H. uncinatus. Biochem. Syst. Ecol.  32: 211-214. ISI IF= 1,110

5.- Tapia L, Torres J, Mendoza L, Urzúa A, Ferreira J, Pavani M, Wilkens M (*), (2004) Effect of 13-epi-Sclaroel on the bacterial respiratory chain.  Planta Med. 70:1058-1063. ISI IF=2,369

6.- Urzúa A(*), (2004) Secondary metabolites in the epiculticle of Haplopappus Foliosus D.C. (Asteraceae). J. Chil. Chem. Soc.  49: 137-141. ISI IF=0,45

7.- Modak B(*), Torres R, Wilkens M, Urzúa A, (2004) Antibacterial activity of compounds isolated of the resinous exudate from Heliotropium sinuatum on phytopathogenic bacteria. J. Chil. Chem. Soc.  49: 1-3. ISI IF=0,45

8.- Urzúa A(*),  Jara F, Tojo E, Wilkens M , Mendoza L, Rezende M C, (2006) A new antibacterial clerodane diterpenoid from the resinous exudates of Haplopappus uncinatus. J. Ethnopharm. 103: 297-301. ISI IF=3,014

9.- Sebastián B, Urzúa A(*),Vines M, (2006) Análisis of surface and volatile compounds of flower heads of introduced plants of Chrysanthemum coronarium L. growing wild in Chile. Flavour and fragrance J. 21: 783-785. ISI IF=1,424

10.- Jara  F, Mascayano  C, Caroli  M C (*), Tirapegui C, Urzúa A, (2006)  A spectral and molecular dynamics simulation study of B-cyclodextrin inclusión complexes with solvatochromic dyes derived from barbituric acid. J. Inclusión Phenomena and Macrocyclic Chem. 54: 95-99. ISI IF=1,886

11.-Sotes G (*), Urzúa A, Sebastián B, (2006) Chemistry of Poulteria splendens and its ecological situation. Biochem. Syst. Ecol.  34: 338-340. ISI IF= 1,110

12.- Urzúa A(*),Santander R, Echeverría J. (2007) Analysis of surface and volatile compounds of flower heads of Flourensia thurifera (Mol) D.C. J. Chil. Chem. Soc.  52: 1244-1245. ISI IF=0,45

13.- Urzúa A(*), Santander R, Echeverría J, Rezende M C, (2007) Secondary metabolites in the  flower heads of Haplopappus berterii (Asteraceae) and its relation with insect-attracting mechanism. J. Chil. Chem. Soc.  52: 1142-1144. ISI IF=0,45

14.- Urzúa A (*),  Iturra B, Sebastian B, Munoz M, (2007)  Chemical components from the surface of Haplopappus bustillosianus. Biochem. Syst. Ecol.  35: 794-796 ISI IF=1,110

15.- Urzúa A (*),  Sotes G, (2008) Essential oils  of Aristolochia chilensis a host plant of Battus polydamas”. J. Chil. Chem. Soc.  53: 1361-1363. ISI IF=0,45

16.- Urzúa A (*), Mendoza L, (2008) Cuticular components from Pseudognaphalium robustum (Asteraceae): chemosystematics considerations”. J. Chil. Chem. Soc.53: 1411-1412. ISI IF=0,45 

17.-  S.Teillier, A. Urzua, Niemeyer H M(*), (2008) Chemical and morphological study of a putative hybrid between Luzuriaga radicans and L. polyphylla (Monocotyledoneae: Luzuriagaceae)” New Zealand Journal of Botany 46: 321-326. ISI IF=0, 846 

18.- Urzúa A (*), Echeverria J, Rezende M C, Wilkens M, (2008) Antibacterial Properties of 3 H-Spiro[1-benzofuran-2,1 '-cyclohexane] Derivatives from Heliotropium filifolium.  Molecules  10: 2385-2393. ISI IF=2,386

19.- Urzúa A (*), Rezende M C, Mascayano C, Vásquez L, (2008) A structure-activity study of antibacterial diterpenoids. Molecules 13: 882-891. ISI IF=2,386

20.- Pinto C F, Troncoso A J, Urzúa A, Niemeyer H M (*),  (2009) Use of volatiles of Aristolochia chilensis (Aristolochiaceae) in host searching by fourth-instar larvae and adults of Battus polydamas archidamas (Lepidoptera: Papilionidae: Troidini). Eur. J. Entomol. 106: 63–68.  ISI IF=1,061

21.- Cabezas N J, Urzúa A, Niemeyer H M (*), (2009) Translocation of isoquinoline alkaloids to the hemiparasite, Tristerix verticillatus from its host, Berberis Montana. Biochem. Syst. Ecol. 37: 225-227 ISI IF=1,110

22.- Mendoza L,  Espinoza P, Urzua A, Vivanco M, Cotoras M, (2009) In vitro Antifungal activity of the diterpenoid 7α-Hydroxy-8(17)-labden-15-oic acid and its derivatives against Botrytis cinerea”. Molecules 14: 1966-1979. ISI IF=2,386

23.- Palacios S M(*), Bertoni A, Rossi Y,  Santander R, Urzúa A, (2009) Efficacy of essential oils from edible plants as insecticides against the house fly, Musca Domestica L. Molecules 14: 1938-1947. ISI IF=2,386

24.- Pinto C F, Troncoso A J, Urzúa A, Niemeyer H M(*), (2009) Aristolochic acids effect the feeding behavior and development of Battus polydamas archidamas larvae. Eur. J. Entomol. 106: 353-361 ISI IF=1,061

25.- J.Torres-Bustos, L. Farías, A. Urzúa, L. Mendoza, Wilkens M (*), (2009) The diterpenoid ent-16-kauren-19-oic acid acts as an uncoupler of the bacterial respiratory chain. Planta Med., 75: 823-828. ISI IF=2,369

26.- Palacios S M(*),, Bertoni A, Rossi Y, Santander R, Urzúa A, (2009) Insecticidal activity of  essential oils from native medicinal plants of Central Argentina against the house fly, Musca  domestica (L.).  Parasitol. Res. 106: 207-212. ISI IF=2,149

27.- Urzúa A (*), R. Santander, G. Sotes,  (2009) Aristolochic acids from Aristolochia bridgesii, a host-plant of Battus polydamas archidamas.  J. Chil. Chem. Soc. 54: 437-438.  ISI IF=0,45

28.- Troncoso A J, Cabezas N J, Faundez E H, Urzua A, Niemeyer H M(*), (2010) Host-mediated  volatile polymorphism in a parasitic plant influences its attractiveness to pollinators. Oecologia  162: 413-42. ISI IF= 3,517

29.- Urzúa A (*), R. Santander, J. Echeverria,  N. Cabezas, SM. Palacios, Y. Rossi (2010) Insecticide      properties of the essential oils from Haplopappus foliosus and Bahia ambrosoides against  the house fly, Musca domestica L.” J. Chil. Chem. Soc. 55: 392-395. ISI IF=0,45

30.- Urzúa A (*),Santander R, Echeverria J,  Villalobos C,  Palacios S M, Y. Rossi Y,  (2010). Insecticidal properties of Peumus boldus Mol. essential oil on the House Fly, Musca    domestica L.  BLACPMA 9:  465-469.  ISI IF= 0,634

31.- Modak B (*), Torres R, Urzúa A,  (2011) Seasonal variation of the flavonoids pinocembrin and 3-O-methylgalangin, in the surface component mixture (resinous exudates and waxy coating) of Heliotropium stenophyllum. J. Chil. Chem. Soc. 56: 392-395. ISI IF=0,45

32.- Urzúa A (*),Di Cosmo D, Santander R, Echeverria J,  Palacios S M, Rossi Y. (2011) Insecticidal effect of Schinus latifolius Mol. essential oil on the House Fly, Musca domestica L. BLACPMA 10: 470-475. ISI IF= 0,634

33.- Urzúa A (*), Sotes G, Echeverria J, (2011) Presence of 3-(pentadec-10-enyl)-catechol allergen in the epicuticular components of Lithrea caustica (Anacardiaceae). BLACPMA 10: 590-594. ISI IF= 0,634

34.- Urzúa A (*), Echeverría, J,  Santander R, (2011) Comparative Chemical Composition of the Essential Oils from Pseudognaphalium robustum, P. heterotrichium and P. cheiranthifolium.” J. Essential Oil Bearing Plants 14: 600-604. ISI IF=0,29

35.- Pinto CF, Urzúa A, Niemeyer H M(*), (2011) Sequestration of aristolochic acids from meridic diets by larvae of Battus polydamas archidamas (Papilionidae: Troidini). Eur. J. Entomol. 108: 41-45. ISI IF=1,061

36.-. Muñoz M A, Urzúa A, Echeverría J, Modak B, Joseph-Nathan P(*)  (2012) Solid State Structure and Absolute Configuration of Filifolinol Acetate.  Nat. Prod. Commun. 6: 759-762. ISI IF=1,242

37.- Munoz M,  Urzúa A, Echeverria  J, Bucio M A, Hernández-Barragán A,  Joseph-Nathan P(*),(2012) Determination of absolute configuration of salvic acid, an ent-labdane from Eupatorium salvia, by vibrational circular dichroism. Phytochemistry  80: 109-114. ISI IF=3,351

38.-Urzua A (*), Echeverria J, Espinoza J, (2012) Lipophilicity and antibacterial activity of flavonols: Antibacterial activity of resinous exudates of Haplopappus litoralis, H. chrysantemifolius and H. scrobiculatus.  BLACPMA 11: 369-376. ISI IF=0,634

39.- Espinoza J, Echeverria J,  Urzúa A (*), Niemeyer H M,  (2012) Withanolid amine and nicotine from Dunalia spinosa (Solanaceae).  BLACPMA 11: 278-284. ISI IF=0,634

40.- Espinoza J,  Urzúa A (*), Echeverria J, (2012) Identification of the components of a non polar extract of the aerial parts of Dunalia spinosa by GC-MS. BLACPMA 11:  86-90. ISI IF=0,634

41.- Urzúa A (*), Modak B, Santander R, Heit C,  Echeverria J, (2012) Insecticidal properties of Heliotropium stenophyllum essential oil on the house fly, Musca domestica L.  BLACPMA 12: 196-200. ISI IF=0,634

Proyectos: 

Investigador responsable

  1. FONDECYT 1030466 “Efecto de la modificación química selectiva de diterpenos sobre la actividad antimicrobiana, determinación del mecanismo de acción”. 2003-2006.
     
  2. FONDECYT 1060033. “Determinación estructural de kairomonas de reconocimiento y aceptación de hospedero en Aristolchia chilensis, percibidas por larvas de Battus    polydamas archidamas”.2006-2008.
     
  3. DICYT 020941. “Actividad insecticida en Musca domestica L. de aceites esenciales de algunas plantas chilenas”. 2009-2011.
     
  4. FONDECYT 1020037. “Sequestration of aristolactams from  Aristolchia chilensis, by larvae of  Battus polydamas archidamas”. 2012-2015.

 

Co-Investigador

  1. FONDECYT 1030813 “Capacidad antioxidante de fitocompuestos aromaticos: Protección de biosuperficies foliares”.  2003-2007.
     
  2. FONDECYT  1040001 “Comportamiento anisotropico de compuestos solvatocromicos en microambientes heterogéneos”. 2004-2007.
     
  3. FONDECYT 1070124 “Interacciones soluto-solvente de sondas solvatocrómicas en solución”. 2007-2009.
     
  4. FONDECYT 1100022 “novel solvato- and halochromic betaines: synthesis, evaluation and development of theoretical models”. 2010-2013.
Otras actividades relevantes: 

Número de tesis dirigidas en los últimos 10 años:

Magister:                   Dirigidas: 5                 En desarrollo: 3          

 

Doctorado:                Dirigidas: 7                 En desarrollo: 2

 

Comité editorial revistas científicas

  • Editor Científico de BLACPMA

Referee de revistas internacionales

  • J. Ethnopharmacology, J. Chil. Chem. Soc., Molecules, etc.

                       

Revisor de proyectos

  • FONDECYT

 

Par evaluador de Postgrado

  • Evaluador de Tesis de Doctorado en los programas de la PUCV, UFRO y U de Santiago

 

Participación en claustro de doctorados

  • Doctorado en Química Universidad de Santiago de Chile