Email: 
bety.matsuhiro@usach.cl
Teléfono: 
27 181 159
Sitio web: 
http://www.experts.scival.com/UdeSantiago/expert.asp?n=BETTY%20MATSUHIRO%20YAMAM…
Abstract

Research is related to:

  1. Structural determination of polysaccharides by chemical and spectroscopic methods.
  2. Chemical modifications of polysaccharides. Synthesis of glycoconjugates.
  3. Carbohydrate derivatives as ligands in the formation of coordination compounds with metals.  
Línea(s) de investigación: 
Química de hidratos de carbono
Jerarquía: 
Titular
Grados académicos /educación: 
Licenciado en Química, Universidad de Buenos Aires, 1961
Doctor en Química, Universidad Buenos Aires, Argentina, 1964.
Publicaciones: 
  1. L.E.Lillo, B. Matsuhiro*. Chemical modifications of 1®4-2-amino-2-deoxy-a-D-galactan. Carbohydr. Polym. 51, 317-325 (2003). IF: 3,987.
  2. J. Costamagna, L.E. Lillo, B. Matsuhiro*, M.D. Noseda, M. Villagrán. Ni(II) complexes with Schiff bases derived from aminosugars as ligands. Carbohydr. Res., 338, 1535-1542 (2003). IF: 2,386.
  3. C. Sáenz*, E. Sepúlveda, B. Matsuhiro. Opuntia spp. Mucilage’s: a functional component with industrial perspectives. J. Arid. Environm., 57, 275-290, 2004. IF: 2,135.
  4. N.P. Chandía, B. Matsuhiro*, E. Mejías, A. Moenne. Alginic acid in Lessonia vadosa: Partial hydrolysis and elicitor properties of the polymannuronic acid fraction. J. Appl. Phycol., 16, 127-133 (2004). IF: 2,411.
  5. P.J. Cáceres, J. Costamagna, A. Danil de Namor, B. Matsuhiro*. Lower rim p-tert-butylcalix[4]arene derivatives containing galactitol pendants. Complexation of 5,11,17,23-tetrakis-(1,1-dimethylethyl)-25,27-dihydroxy-26,28-Bis-2-N-(1-deoxy-D-galactityl)-aminoethoxycalix[4]arene with Pb(II) and F(-I). J. Chil. Chem. Soc., 49, 281-284 (2004).IF: 0,65.
  6. J. Zúñiga, L. Lillo, J. Shin, R.L. Machavarapu, T. Quiroga, M. Goycolea, B. Matsuhiro, L. Aron-Hott, H.P. Godfrey,  F.C. Cabello*.  Salmonella enterica serovar Typhi O:1,9,12 polysaccharide-protein conjugate as typhoid fever diagnostics., J. Clin. Microbiol., 43, 4545-4550 (2005). IF: 4,399.
  7. N.P. Chandía, B. Matsuhiro*, J.S. Ortiz, A. Mansilla. Carbohydrates from the sequential extraction of Lessonia vadosa (Phaeophyta). J. Chil. Chem. Soc., 50, 501-504 (2005). IF: 0,65.
  8. B. Matsuhiro*, A.F. Conte, E.B. Damonte, A.A. Kolender, M.C. Matulewicz, E.G. Mejías, C.A. Pujol, E.A. Zúñiga. Structural analysis and antiviral activity of a sulfated galactan from Schizymenia binderi (Gigartinales, Rhodophyta). Carbohydr. Res., 340, 2392-2402 (2005). IF: 2,386.                
  9. B. Matsuhiro*, L.E. Lillo, C. Sáenz, C.C. Urzúa, O. Zárate.  Chemical characterization of the mucilage from fruits of Opuntia ficus indica. Carbohydr. Polym., 63, 263-267 (2006). IF: 3,987.
  10. B. Matsuhiro*, L.C. Presle, C.Sáenz, C.C. Urzúa. Structural determination and chemical modification of the polysaccharide from seeds of Prosopis chilensis Mol. (Stuntz). J. Chil. Chem. Soc., 51, 809-813 (2006). IF: 0,65.
  11. E.A. Zúñiga, B. Matsuhiro*, E. Mejías. Preparation of a low molecular weight fraction by free radical depolymerization of the sulfated galactan from Schizymenia binderi (Gigartinales, Rhodophyta) and its anticoagulant activity. Carbohydr. Polym., 66, 208-215 (2006). IF: 3,987.
  12. D. Laporte, J. Vera, N.P. Chandía, E.A. Zúñiga, B. Matsuhiro, A. Moenne*. Structurally-unrelated algal oligosaccharides differentially stimulate growth and defense against Tobacco Mosaic Virus in tobacco plants. J. Appl. Phycol., 19, 79-88 (2007). IF: 2,411.
  13. B. Matsuhiro*, S.E. Torres, J. Guerrero. Block structure in alginic acid from Lessonia vadosa (Laminariales, Phaeophyta). J. Chil. Chem. Soc., 52, 1095-1098 (2007). IF: 0,65
  14. D. Leal, B. Matsuhiro*, M. Rossi, F. Caruso. FT-IR spectra of alginic acid block fractions in three species of brown seaweeds. Carbohydr. Res., 343, 308-316 (2008). IF: 2,386
  15. N.P. Chandía, B. Matsuhiro*. Characterization of a fucoidan from Lessonia vadosa (Phaeophyta) and its anticoagulant and elicitor properties. Int. J. Biol. Macromol., 42, 235-240 (2008). IF: 2,45.
  16. F. Fuenzalida, P. Dreyse, D. Villagra, B. Matsuhiro, L. Mendoza, M.J. Aguirre, M. Isaacs*. Electrochemical reduction of SO2 on poly-Co-3-tetraaminophenylporphyrin glassy carbon modified electrode. J. Coord. Chem., 62, 130-140 (2009). IF: 1,547.
  17. P. Bravo, Y.Y. Chen, G. Ramirez, M.J. Canales, B. Matsuhiro, L. Mendoza, M. Isaacs, M. C. Arevalo, M.J. Aguirre*. Electrooxidation and determination of sulfite in ethanol-water solutions using poly-Cu(II)-tetrakis(X-tetraaminophenyl)-Porphyrin/glassy carbon modified electrodes.  Collect. Czech.Chem. Commun., 74, 545-557 (2009). IF: 1,28.
  18. C. García, D.Villagra, F. Caruso, M. Rossi, B. Matsuhiro, L. Mendoza, M. J. Aguirre, M. Isaacs*. Synthesis, structure and electrochemical properties of the cationic complex tris-(imidazolidine-1,10-phenanthroline)iron(II). Inorg. Chem. Commun. 12, 392-395 (2009). IF: 1,901.
  19. M.J. Aguirre, M. Isaacs, B. Matsuhiro*, L. Mendoza, E.A. Zúñiga. Characterization of a neutral polysaccharide with antioxidant capacity from red wine. Carbohydr. Res., 344, 1095-1101 (2009). IF: 2,386.
  20. G. Ramírez, M.C. Goya, L. Mendoza, B. Matsuhiro, M. Isaacs, Y.Y. Chen, M.C. Arévalo, J. Henríquez, W. Cheuquepan, M.J. Aguirre*. Iron porphyrin-modified electrodes: influence of the method of modification on the stability and electroactivity in oxidation of sulfite or hydrogensulfite in ethanol–water solutions. J. Coord. Chem., 62, 2782-2791 (2009). IF: 1,547.
  21. B. Matsuhiro*, R. Torres, E.A. Zuniga, M.J. Aguirre, L. Mendoza, M. Isaacs. Determination of low molecular weight carbohydrates in Cabernet Sauvignon red wines. J. Chil. Chem. Soc., 54, 405-407 (2009). IF: 0,65.
  22. K. Calfumán, M.J. Aguirre, D. Villagra, C. Yañez, C. Arevalo, B. Matsuhiro, L. Mendoza, M. Isaacs*. Nafion/tetraruthenated porphyrins glassy carbon modified electrode: Characterization and voltammetric studies of sulfite oxidation in water-ethanol solutions., J. Solid. State Electrochem., 14, 1065-1072 (2010). IF: 2,131.
  23.  M.J. Aguirre, Y.Y. Chen, M. Isaacs, B. Matsuhiro*, L. Mendoza, S. Torres.  Electrochemical behaviour and antioxidant capacity of anthocyanins from Chilean red wine, grape and raspberry. Food Chem., 121, 44-48 (2010). IF: 4,268.
  24. K. Calfumán, M. García, M.J. Aguirre, B. Matsuhiro, L. Mendoza, M. Isaacs*.  Electrochemical reduction of S(IV) compounds in water-ethanol solutions at nafion/tetraruthenated porphyrins glassy carbon modified electrodes. Electroanalysis, 22, 338-344 (2010). IF: 2,372.
  25. M. M. Campos-Vallette, N. P. Chandía, E. Clavijo, D. Leal, B. Matsuhiro*, I. O. Osorio-Román,  S. Torres. Characterization of sodium alginate and its block fractions by Surface-Enhanced Raman Spectroscopy. J. Raman Spectros., 41, 758-763 (2010). IF: 3,087.
  26. W. Cheuquepán, D. Villagra, M.I. Azócar, G. Ramírez, Y.Y. Chen, B. Matsuhiro, L. Mendoza, M. Isaacs, M.J. Aguirre*. Effect of the number of substituents on the behavior of modified electrodes with cobalt porphyrins substituted with a different numbers of bis(methoxyphenyl) groups toward the oxidation of sulfite. J. Chil. Chem. Soc., 55, 253-256 (2010). IF: 0,65.
  27. I.O.  Osorio-Román*, R.F. Aroca, J. Astudillo, B. Matsuhiro, C. Vásquez, J.M. Pérez. Characterization of bacteria using its O-antigen with surface enhanced Raman scattering. Analyst 135, 1997-2001 (2010). IF: 4,23.
  28. T. Barahona, N.P. Chandía, M. V. Encinas, B. Matsuhiro*, E. A. Zúñiga.  Antioxidant capacity of sulfated polysaccharides from seaweeds. A kinetic approach., Food Hydrocolloids, 25, 529-535 (2011). IF: 3,46.
  29. G. Cárdenas-Jirón, D. Leal, B. Matsuhiro*, I.O. Osorio-Román.  Vibrational spectroscopy and density functional theory calculations of poly-D-mannuronate and heteropolymeric fraction of sodium alginate. J. Raman Spectros. 42, 870-878 (2011). IF: 3,087.
  30. S. Torres, G. Ferraudi*, M.J. Aguirre, M. Isaacs, B. Matsuhiro, N.P. Chandía, L. Mendoza On the ligand to metal charge transfer photochemistry of the copper (II) complexes of quercetin and rutin. Helv. Chim. Acta, 94, 293-300 (2011). IF: 1,47.
  31. G. Ferraudi*, N.P. Chandía, B. Matsuhiro, S. Torres. Observations on the mechanisms of the thermal and photoinduced oxidation of D-mannitol and fucoidan by transition metal complexes and inorganic radicals. J. Coord. Chem., 64, 377-389 (2011). IF: 1,547.
  32. J. Vera, J. Castro, A. González,  H. Barrientos, B. Matsuhiro, P.  Arce, G. Zúñiga,  A. Moenne*. Long-term protection against tobacco mosaic virus induced by the marine alga oligo-sulphated-galactan Poly-Ga in tobacco plants.. Mol. Plant Pathol. 12, 437-447 (2011). IF: 3,899.
  33. C. García, C. Domínguez, A. Aliaga, B. Matsuhiro, L. Mendoza, M.J. Aguirre, M. Isaacs*. Electrochemical properties of a conducting film derived from iron (II) tris-diaminepolypyridyl complex in the S (IV) oxoanions reduction. Electroanalysis, 23 (6), 1401-1409 (2011). IF: 2, 372.
  34. M.J. Aguirre, M. Isaacs, B. Matsuhiro*, L. Mendoza, L.S. Santos, S. Torres. Anthocyanin composition in aged Chilean Cabernet Sauvignon red wines.  Food Chem., 129, 514-519 (2011). IF: 4,268.
  35. L. Mendoza*, B. Matsuhiro, M.J. Aguirre, M. Isaacs, G. Sotes, M. Cotoras, R. Melo Characterization of phenolic acids profile from Chilean red wines by high-performance liquid chromatography. J. Chil. Chem. Soc., 56, 688-691 (2011). IF: 0,65
  36. F. Caruso*, L. Mendoza, P. Castro, M. Cotoras, M. Aguirre, B. Matsuhiro, M. Isaacs, M. Rossi, A. Viglianti, R. Antonioletti. Antifungal activity of resveratrol against Botrytis cinerea is improved using 2-furyl derivatives. PLoS ONE, 6(10):e25421, doi:101371 (2011). IF: 4,09.
  37. T. Barahona, M. V. Encinas, A. Mansilla, B. Matsuhiro*, E. A. Zuñiga A sulfated galactan with antioxidant capacity from the green variant of tetrasporic Gigartina skottsbergii (Gigartinales, Rhodophyta). Carbohydr. Res., 347, 114-120 (2012). IF: 2,386.
  38. B. Matsuhiro*, I. Osorio-Román, R. Torres. Vibrational spectroscopy characterization and anticoagulant activity of a sulfated polysaccharide from sea cucumber Athyonidium chilensis. Carbohydr. Polym. 88, 959-965 (2012). IF: 3,987.
  39. P. Dreyse, D. Quezada, J. Honores, M.J. Aguirre, L. Mendoza, B. Matsuhiro, D. Villagra, M. Isaacs*. Determination of S(IV) oxoanions at poly-[Ru(5-NO2-phen)2Cl]tetrapyridilporphyrin glassy carbon modified electrode. Electroanalysis, 24, 1703-1708 (2012). IF: 2,372
Proyectos: 

Investigador responsable

  1. “Polisacáridos sulfatados de algas: estructura química y propiedades biológicas”, FONDECYT 1010594 (2001-2004).
  2. “Polisacáridos solubles de algas del género Lessonia”,  DICYT (2005-2006).
  3. “Diseño de un sensor electroquímico para sulfito y determinación electroquímica de la capacidad antioxidante de fenoles en vino. Programa Bicentenario de Ciencia y Tecnología. Proyecto Anillo ACT 24”, CONICYT-Banco Mundial (2006-2009).
  4. “Determinación estructural de polisacáridos sulfatados y estudio de algunas de sus propiedades biológicas”, DICYT (2009-2010).
  5. “Determinación estructural y modificación química de polisacáridos de algas”, DICYT (2011-2012).

 

Co-Investigador

  1. “Cultivo y biotecnología de Ahnfeltia plicata, nueva alternativa en la producción de ficocoloides para la Región de Magallanes". Proyecto FONDEF (2010-2013).
  2. “Formulación de nanofibras de quitosano contenedores de compuestos antioxidantes para su potencial uso en neuroprotección” Proyecto Fundación Copec-UC, Nº 8CO55” (2011-2013).
Otras actividades relevantes: 

Número de tesis dirigidas en los últimos 10 años:

Magister:            Dirigidas:      1               En desarrollo:      1

Doctorado:         Dirigidas:      7               En desarrollo:      2

 

Otras publicaciones y patentes

  • Alginic acids from Phaeophyta of Magellan Region (Chile). B. Matsuhiro*, D. Leal, A. Mansilla. Capítulo en libro "Alginates: Production, Types and Applications", M. Molina, A.J. Quiroga Eds., Nova Publishers, Nueva York (2012), pp. 217-234.     

Patente en trámite

  •  “Fabricación de electrodos de carbón”, M.J. Aguirre, C. Arevalo, M. Isaacs, B. Matsuhiro, L. Mendoza, J. Romero.

 

Comité editorial revistas científicas

  • Miembro del comité editorial de Journal of Chilean Chemical Society

Referee de revistas internacionales

  • Carbohydrate Research, Carbohydrate Polymers, Food Chemistry, International Journal of Biological Macromolecules, Journal of Chilean Chemical Society, Journal of Agricultural and Food Chemistry, etc.

                       

Revisor de proyectos

  • FONDECYT
  • CONICET, Argentina
  • Universidades Nacionales

 

Participación en claustro de doctorados

Doctorado en Química, Facultad de Química y Biología, Usach.

Email: 
carolina.mascayano@usach.cl
Teléfono: 
27 181 156

Abstract

Our research focuses on Bioorganics and Medicinal Chemistry, specifically on synthesizing organic and organometallic compounds. Our objective is to develop innovative scaffolds that function as dual COX-2/5-LOX inhibitors. Additionally, we conduct in vitro assays to test these compounds with the enzymes involved in the arachidonic acid pathway. To complement our research, we utilize docking and molecular dynamics techniques.

Línea(s) de investigación: 
- Química Computacional
- Química Médica
- Síntesis y evaluación biológica de inhibidores COX-2/5-LOX
Jerarquía: 
Asociado
Grados académicos /educación: 
Doctor en Química, Facultad de Química y Biología, Universidad de Santiago de Chile, 2006 /
Química, Facultad de Química y Biología, Universidad de Santiago de Chile 2000 /
Licenciado en Química, Facultad de Química y Biología, Universidad de Santiago de Chile 2000
Publicaciones: 

10. Ureta-Zañartu, M. S., Mascayano, C., & Gutiérrez, C. (2015). On the dramatic increase with chain length of the oxidazability of linear saturated aliphatic alcohols on gold in alkaline media. Electrochimica Acta, 165, 232-238. ISI (4.036)

9. Toro-Ascuy, D., Tambley, C., Beltran, C., Mascayano, C., Sandoval, N., Olivares, E., ... & Cortez-San Martín, M. (2015). Development of a Reverse Genetic System for Infectious Salmon Anemia Virus: Rescue of Recombinant Fluorescent Virus by Using Salmon Internal Transcribed Spacer Region 1 as a Novel Promoter. Applied and environmental microbiology, 81(4), 1210-1224.ISI (3.668)

8. Mascayano, C., Espinosa, V., Sepúlveda‐ Boza, S., Hoobler, E. K., Perry, S., Diaz, G., & Holman, T. R. (2014). Enzymatic Studies of Isoflavonoids as Selective and Potent Inhibitors of Human Leukocyte 5‐ Lipo‐ Oxygenase.Chemical biology & drug design.ISI (2.507).

7. Modak, B., Torres, P., Mascayano, C., Torres, R., Urzúa, A., & Valenzuela, B. (2014). Derivatives of 3H-spiro1-benzofuran-2, 1’-cyclohexanes: immunostimulants for veterinary use. Boletín latinoamericano y del Caribe de plantas medicinales y aromáticas, 13(4), 375-380.ISI (0.507).​

6. Torres, R., Mascayano, C., Nunez, C., Modak, B., & Faini, F. (2013). COUMARINS OF HAPLOPAPPUS MULTIFOLIUS AND DERIVATIVE AS INHIBITORS OF LOX: EVALUATION IN-VITRO AND DOCKING STUDIES.Journal of the Chilean Chemical Society, 58(4), 2027-2030.ISI (0.469)

5. Mascayano, C., Espinosa, V., Sepúlveda‐ Boza, S., Hoobler, E. K., & Perry, S. (2013). In Vitro Study of Isoflavones and Isoflavans as Potent Inhibitors of Human 12‐ and 15‐ Lipoxygenases. Chemical biology & drug design, 82(3), 317-325. ISI (2.507)

4. Rezende, M. C., Mascayano, C., Briones, L., & Aliaga, C. (2011). Sensing different micellar microenvironments with solvatochromic dyes of variable lipophilicity. Dyes and Pigments, 90(3), 219-224.ISI (3.966)

3. Castro-Nallar, E., Cortez-San Martín, M., Mascayano, C., Molina, C., & Crandall, K. A. (2011). Molecular phylodynamics and protein modeling of infectious salmon anemia virus (ISAV). BMC evolutionary biology, 11(1), 349.ISI (3.407)

2. Mascayano, C., Caroli Rezende, M., Rivera, Y., & Espinosa, V. (2011). Isoflavans derivatives as inhibitors of soybean lipoxygenase: in-vitro and docking studies. Journal of the Chilean Chemical Society, 56(4), 935-937. ISI (0.469)

1. Mascayano, C., Núñez, G., Acevedo, W., & Rezende, M. C. (2010). Binding of arachidonic acid and two flavonoid inhibitors to human 12-and 15-lipoxygenases: a steered molecular dynamics study. Journal of molecular modeling, 16(5), 1039-1045.ISI (1.736)

Proyectos: 
  • FONDECYT Enhancement of endothelium signaling by dietary polyphenols and potassium supplements in control and STZ-diabetic rats, 2017-2021. Co investigador.
  • DICYT Síntesis, Propiedades Anti-inflamatorias y Estudios  Computacionales de Derivados de Chalconas como Inhibidores de 5- LOX  2016-2018 Investigador Principal
  • FONDECYT Organometallic complexes linked to macrocycle groups by a chromophore bridging ligand, as potential optical and electrochemical sensors for the detection of metal ions. 2015-2019. Rol: Co investigador.
  • FONDECYT. New Isoflavanones And Isoflavans Derivatives As Lipoxygenase Inhibitors: Computational Studies, Synthesis And Biological Assay, 2012-2015. Investigador principal.
  • FONDEF Generación y desarrollo de una vacuna recombinante eficaz contra el circovirus porcino Tipo 2 potenciada con citoquinas inmuno-reguladoras: una solución biotecnológica para la porcicultura nacional, 2012-2015. Co investigador.
  • DICYT. Cumarinas 7-o preniladas ¿Un modelo interesante de fármacos antiinflamatorios?, 2011-2013. Co investigador.
  • FONDECYT Novel Solvato- And Halochromic Betaines: Synthesis, Evaluation And Development Of Theoretical Models, 2010-2014. Co investigador.
  • DICYT. Síntesis y evaluación biológica de isoflavonoides como inhibidores de 12 y 15-lipoxigenasa humana, a partir de un diseño in silico. 2010-2012. Investigador principal.
  • FONDECYT Molecular modelling studies of enzyme-inhibitor interactions in human platelet lipoxygenases, 2008-2009 Investigador Principal
  • FONDECYT Interacciones soluto-solvente de sondas solvatocromicas  en solución 2007-2009 Co-investigador

 

Otras actividades relevantes: 

PATENTES

  • Vacuna recombinante contra Circovirus Porcino potenciada con un inmunomodulador. Aceptada Código 2016-02746. Jorge Toledo, Ximena Sepulveda, Alvaro Ruiz, Oliberto Sanchez, Marcelo Cortez, Emilio Lamazares, Aura Villamil, Fernando Guitierrez, Carolina Mascayano. (2016)

 

Dirección de Tesis de Doctorado

Autor: Erick Flores

Título de la tesis: Síntesis caracterización y estudio de complejación de tiazolez organometálicos funcionalizados con fragmentos receptores

Programa de posgrado (magíster, doctorado): Doctorado en Química

Fecha de aprobación: En Desarrollo

 

Autor: Alejandra Muñoz

Título de la tesis: Determinación estrcutural de los metabolitos secundarios de parte aérea de Adesmis Arborea y Lithrea Casutica. Estudio como potenciales inhibidores de procesos inflamatorios mediante la inhibición de la enzima 5-lipoxigenasa

Programa de posgrado (magíster, doctorado): Doctorado en Química

Fecha de aprobación: En Desarrollo

 

Autor: Javier Echeverria Morgado

Título de la tesis: Estudio de Estructura-actividad antibacteriana de derivados hemisintéticos del ácido 7-b-hidroxi-ent-labd-8(17)-en-15-oico. Análisis Computacional de la interacción diterpeno membrana bacteriana.

Programa de posgrado (magíster, doctorado): Doctorado en Química

Fecha de aprobación: 2 de Febrero 2012

 

Autor: Judith Faundez

Título de la tesis: 

Programa de posgrado (magíster, doctorado): Doctorado en Química

Fecha de aprobación: Primer Año

Email: 
marcos.caroli@usach.cl
Teléfono: 
227 181 035
Sitio web: 
http://www.experts.scival.com/UdeSantiago/expert.asp?n=MARCOS%20CAROLI%20REZENDE…
Áreas de investigación: 
Química Orgánica
Físico-Química Orgánica
Línea(s) de investigación: 
- Solvato- y halo-cromismo: síntesis de nuevas sondas, estudio de sus propiedades y de su comportamiento en solución.
- Interacciones soluto-solvente en solución
- Sistemas micro-heterogéneos y mezclas binarias
- Mecanismos de reacciones orgánicas
Jerarquía: 
Titular
Grados académicos /educación: 
Estadía post-doctoral, École Normale Supérieure, Paris, Francia, 1985
Doctor en Química (Ph.D.), University of East Anglia, Inglaterra. 1980
Magister en Química (M.Sc.), Universidade Federal de S. Catarina, 1976
Licenciado en Química, Universidad Federal de Rio de Janeiro, 1970
Publicaciones: 

Productividad en los últimos cinco años:

30. “Microwave-Promoted Synthesis of 4-Arylpyrimidines by Pd-Catalyzed Suzuki-Miyaura Coupling of 4-Pyrimidyl Tosylates in Water” J.Rodriguez-Aguilar, B. Ordóñez, M.Vidal, M.C.Rezende, M.Domínguez, SynOpen 2017, 1, 24-28.

29. "Theoretical insights into the regioselectivity of a Pictet-Spengler reaction: transition state structures leading to salsolinol and isosalsolinol." Iriux Almodóvar, Marcos Caroli Rezende, Bruce Cassels, Macarena García-Arriagada, J.Phys.Org.Chem. 2017, 30, e3666.

28. “Thermohalochromism of phenolate dyes conjugated with nitro-substituted aryl groups”, L. Hermosilla, M. C. Rezende, V. G. Machado, R. I. Stock, Spectrochim.Acta A, 2017, 173, 556-561.

27. “Aggregation phenomena in photobicyclised pyridinium salts” A. Aracena, M. C. Rezende, M. V. Encinas, C. Vergara and S. O. Vasquez-, New J. Chem., 2017,41, 14589-14594.

26. “Antioxidant-spotting in micelles and emulsions”, C.Aliaga, A.L.deArbina, C. Pastenes , M.C.Rezende, Food Chemistry, 2018, 245, 240-245.

25. “Solvatochromism of conjugated 4-N,N-dimethylaminophenylpyridinium donor-acceptor pairs”, M.Vidal, M.C.Rezende, C. Pastenes, C.Aliaga, M.Domínguez. New J. Chem., 2018, 42, 4223-4231.

24. “Solvatochromic behavior of substituted 4-(nitrostyryl)phenolate dyes in pure solvents and in binary solvent mixtures composed of water and alcohols”, R. I. Stock , C. Sandri , M. C. Rezende, V. G. Machado , J.Mol.Liq. 2018, 264,327-336. 

23. “On the Interactions of TEMPO radicals with gold nanoparticles”, C.Aliaga, S. Michea, C. Pastenes, J.Salazar, M.C.Rezende, New J.Chem., 2018, 42, 9764-9770.

22. “Reverse Solvatochromism of Imine Dyes Comprised of 5-Nitrofuran-2-yl or 5-Nitrothiophen-2-yl as Electron Acceptor and Phenolate as Electron Donor”, C.E.A.de Melo, C.R.Nicoleti, M.C.Rezende, A.J.Bortoluzzi, R.S.Heying, R.S.Oliboni, G.F.Caramori, V.G.Machado, Chem.Eur. J. 2018, 24, 9364-9376.

21. “Visualization of phase-transfer catalysis through charge-transfer complexes”, M. C. Rezende, C. Aliaga, G. Barriga, M. Vidal, J.Chem.Ed., 2018, 95 (9), 1631-1635.

20. “The Solvatofluorochromism of 2,4,6-Triarylpyrimidine Derivatives”, J.Rodríguez-Aguilar, M.Vidal, C.Pastenes, M.C.Rezende, C.Aliaga, M.Domínguez, Photochem. Photobiol. 2018,  94, 1100-1108.

19. "Building Pyridinium Molecular Wires as Axial Ligands for Tuning the Electrocatalytic Activity of Iron Phthalocyanines for the Oxygen Reduction Reaction" A. Pizarro, G.A. Anjari, C.Gutiérrez-Cerón, D.Cortés-Arriagada, F. Bernardi, C. Berrios, J. Silva, M.C. Rezende, J. Zagal, R. Oñate, I. Ponce. ACS Catalysis, 2018, 8, 8406-8419.

18. “Influence of the bite natural angle of bidentate biphosphine ligands in the syngas-free branched hydroformylation of b-functionalized olefins”, M. Vilches-Herrera, M.Concha-Puelles, N.Carvajal, J.Molina, R.Santander, M.C.Rezende, S.Luehr, Cat.Comm. 2018, 116, 62-66.

17. “Molecular conductance versus inductive effects of axial ligands on the electrocatalytic activity of self-assembled iron phthalocyanines: The oxygen reduction reaction”, C.Gutiérrez-Ceron, R. Oñate, J.H.Zagal, A. Pizarro, J.F.Silva, C. Castro-Castillo, M.C.Rezende, M.Flores, D. Cortés-Arriagada, A. Toro-Labbé,  L.M.Campos,  L.Venkataraman, I.Ponce, Electrochim. Acta, 2019, 327, 134996.

16. “The inverted solvatochromism of protonated ferrocenylethenyl-pyrimidines: the first example of the solvatochromic reversal of a hybrid organic/inorganic dye”, M.Vidal, C.Pastenes, M.C.Rezende, C.Aliaga, M.Domínguez Org. Chem. Front., 2019,6, 3896-3901.

15. "Insights into the halochromism of a bithiophene π* probe”, M.Domínguez, R. Mera-Adasme, M.C.Rezende, Spectrochim.Acta A, 2019, 222, 117264.

14. “Interaction of Nitroxide Radicals with an Au8 Nanostructure: Theoretical and Calorimetric Studies”, C.Aliaga, P.Fuentealba, F. Muñoz, C.Pastenes, M.C.Rezende, E.Spodine, C.Cárdenas, J.Phys.Chem.C 2019, 123, 21713-21720.

13. "Solvatofluorochromism of conjugated 4-methoxyphenyl-Pyridinium electron donor-acceptor pairs”, C.Aliaga, M.Vidal, C.Pastenes, M.C.Rezende, M.Domínguez, Dyes and Pigments, 2019, 166, 395-402.

12. "The location of amphiphobic antioxidants in micellar systems: The diving-swan analogy”,  A. L. de Arbina, S. Losada-Barreiro, M.C. Rezende, M.Vidal, C. Aliaga, Food Chem. 2019, 279, 288-293.

11. “On the physical-chemical nature of solvent polarizability and dipolarity”,  R. Mera-Adasme, M.C. Rezende, M. Domínguez , Spectrochim.Acta A, 2020, 229, 118008.

10. “A comparison of multiparametric methods for the interpretation of solvent-dependent chemical processes”, C.Aliaga, M.Domínguez, P.Rojas, M.C.Rezende, J.Mol.Liquids, 2020, 312, 113362. 

9. “Solvatochromism of dyes inspired in Effenberger’s probe”, C.E.A. de Melo, M.Domínguez, M.C.Rezende, V.G.Machado, Dyes and Pigments, 2021,184, 108757.

8. “Preferential solvation index as a tool in the analysis of the behavior of solvatochromic probes in binary solvent mixtures”, Crislaine Sandri, Carlos E.A. de Melo , Luciano A. Giusti , Marcos C. Rezende , Vanderlei G. Machado, J.Mol.Liquids 2021, 328, 115450.

7. “The use of a preferential-solvation index (PSI) for the comparison of halochromic systems”,  C.Pastenes, V.G. Machado, M.C.Rezende, J.Mol.Liquids  2021, 334, 115944.

6. “The use of non-ideality parameters for the analysis of thermodynamic properties of binary mixtures “,  M.C.Rezende, V.G.Machado,S. Morales, M.Vidal, ACS Omega 2021, 6, 16553-16564.

5. “Applications of a preferential–solvation index (PSI) for the comparison of binary mixtures with ionic liquids”, S. Morales, C. Pastenes, V. G. Machado, M. C. Rezende, J.Mol.Liquids. 2021, 343, 117644.

4. “Alkylated Benzodithienoquinolizinium Salts as Possible Non-Fullerene Organic N -Type Semiconductors: An Experimental and Theoretical Study”, A. Aracena, M. C. Rezende,  M. García, K. Muñoz-Becerra,K. Wrighton-Araneda, C. Valdebenito,  F. Celis, O. Vásquez, Materials 2021, 14, 6239.

3. “Location, Orientation and Buoyance Effects of Radical Probes as Studied by EPR” C.Aliaga, M.C.Rezende,  in Lipid Oxidation in Food and Biological Systems, editor C.Bravo-Díaz,  Part II, ps. 133-150, Springer Nature, Switzerland, January 2022.

2. “Binary mixtures with deep eutectic Solvents: Comparing properties with a Non–Ideality approach” V.G.Machado, D. Millán, M.C.Rezende, J.Mol.Liquids. 2022, 359, 119259.

1. “Solvent effects on the wood deligni cation with sustainable solvents “ D.Millán, F. González-Turen, J. Perez-Recabarren , C. Gonzalez-Ponce , M. C. Rezende , A. M. C. Lopes , International Journal of Biological Macromolecules  2022, 211, 490–498.

Proyectos: 

(Últimos cinco años)

  • Fondecyt 1200192, 2020-2023” Radical probes, antioxidants and fluorescent markers in micro- heterogeneous media”, Investigador alterno
  • Fondecyt 1160486, 2016-2019, “Nitroxide-based probes in micro-heterogeneous media: micelles and nanoparticles.”, Investigador alterno.
  • Fondecyt 1230004, 2023-2026, “Theoretical studies and applications of chemical processes in binary mixtures of ionic liquids and/or deep eutectic solvents”, Investigador principal
  • Fondecyt 1190045, 2019-2022,” Properties and applications of new perichromic probes and theoretical interpretation of their solvatochromism”, Investigador principal
  • Fondecyt 1140212, 2014-2017, “Perichromic dyes in homogeneous media and adsorbed on nanoparticles”, Investigador principal

 

Email: 
gloria.cardenas@usach.cl
Teléfono: 
227 181 137
Sitio web: 
Página Académica

Abstract

Our research is focused on the application of quantum chemistry to characterize the molecular and electronic structures, predict the chemical reactivity, and the photophysical and charge transport properties. The main research lines are applied to free and metal porphyrins, expanded porphyrins, phthalocyanines, organic dyes, nanocarbon materials (graphene, fullerene), and semiconductors (TiO2, SnO2). These correspond to (a) Molecular optoelectronic for solar cells, (b) Molecular electronic devices with single molecular junctions, (c) Mechanisms of dye photodegradation and Photodegradation of emerging contaminants in wastewater treatment, (d) Rational design of conductive metal-organic frameworks.
Línea(s) de investigación: 
Química Teórica Cuántica.
Jerarquía: 
Titular
Grados académicos /educación: 
Profesor de Química y Ciencias Naturales, Universidad Metropolitana de la Educación, Santiago, Chile, Marzo de 1987.
Magister en Ciencias Químicas, Facultad de Ciencias, Universidad de Chile, Santiago, Marzo de 1993.
Doctor en Ciencias con mención en Química, Facultad de Ciencias, Universidad de Chile, Santiago, Chile, Noviembre de 1996.
Publicaciones: 
  1. “Doping Effects in the Charge Transport of Graphene-Porphyrins”, Gloria Cárdenas-Jirón, Yanara Figueroa, Narendra Kumar, Jorge M. Seminario, Journal of Physical Chemistry C, (2015) accepted with revision. ISI
  2. “Tautomerization Mechanism and Spectral Properties of Porphyrin-Glucose Complexes as Models of Antibacterial Material”, M. Isabel Menéndez, Ramón López, Mauricio Yañez, Gloria Cárdenas-Jirón, submitted to Theoretical Chemistry Accounts, (2015) accepted with revision. ISI
  3. “Understanding the hydrolysis mechanism of ethyl acetate catalyzed by an aqueous molybdocene: A computational chemistry investigation”, Elkin Tílvez, Gloria I. Cárdenas-Jirón, María I. Menéndez, Ramón López, Inorganic Chemistry, 54 (2015) 1223-1231. ISI
  4. "Functionalized Graphene and Cobalt Phthalocyanine based Materials with Potential Use for Electrical Conduction", Gloria I. Cárdenas-Jirón, Paola León-Plata, Jorge M. Seminario, in “Design and Applications of Nanomaterials for Sensors” J.M. Seminario (Ed.) in Series: Challenges and Advances in Computational Chemistry and Physics, Vol. 16, (2014) pp. 185-215, ISBN 978-94-017-8847-2, Springer Dordrecht Heidelberg London New York.
  5. “Theoretical Assessment of the Photosensitization Mechanisms of Porphyrin-Ruthenium(II) Complexes for the Formation of Reactive Oxygen Species”, Laura E. Coitiño, Andy Mella, Gloria I. Cárdenas-Jirón, Journal of Photochemistry and Photobiology A: Chemistry, 294 (2014) 68-74. ISI
  6. “Electron Transport Properties through Graphene Oxide-Cobalt Phthalocyanine Complexes”, Gloria I. Cárdenas-Jirón, Paola León-Plata, Diego Cortes-Arriagada, Jorge M. Seminario, J. Phys. Chem. C, 117 (2013) 23664−23675. ISI
  7. “Assessment of the Photosensitization Properties of Cationic Porphyrins in Interaction with DNA Nucleotide Pair”, Gloria I. Cárdenas-Jirón, Luis Cortez, Journal of Molecular Modeling, 19 (2013) 2913-2924. ISI
  8. “A Three-Layer ONIOM Model for the Outside Binding of Cationic Porphyrins and Nucleotide Pair DNA”, Gloria I. Cárdenas-Jirón, Luis Cortez-Santibañez, Journal of Molecular Modeling, 19 (2013) 811-824. ISI
  9. “Nitric Oxide Oxidation by Substituted Nickel Phthalocyanines: A Theoretical Viewpoint”, Gloria I. Cárdenas-Jirón, Cristhy Gonzalez, Julie Benavides, J. Phys. Chem. C, 116 (2012) 16979−16984. ISI
  10. “Theoretical Study on the Electronic Excitations of a Porphyrin-Polypyridyl Ruthenium(II) Photosensitizer”, Gloria I. Cárdenas-Jirón, Cristina Barboza, Maria Isabel Menéndez, Ramón López, J. Phys. Chem. A,115 (2011) 11988–11997. ISI
  11. “Electrical Characteristics of Cobalt Phthalocyanine Complexes Adsorbed on Graphene”, Gloria I. Cárdenas-Jirón, Paola Leon-Plata, Diego Cortes-Arriagada, Jorge M. Seminario, J. Phys. Chem. C, 115 (2011) 16052-16062. ISI
  12. “A Through Space Charge Transfer Mechanism for Explaining the 2-Chlorophenol Oxidation on a Tetrasulphonated Nickel(III) Phthalocyanine”. Diego Cortés-Arriagada, Gloria I. Cárdenas-Jirón. Comput. Theor. Chem., 963 (2011) 161-167. ISI
  13. “Vibrational spectroscopy and density functional theory calculations of poly-D-mannuronic acid and heteropolymeric fractions from sodium alginate”. Gloria Cárdenas-Jirón, David Leal, Betty Matsuhiro, Igor O. Osorio-Román, J. Raman Spectrosc., 42 (2011) 870-878. ISI
  14. “Quantitative Structure Property Relationships To Evaluate the Photosensitizing Capability in Porphyrins and Chlorins”. Gloria I. Cárdenas-Jirón, Mireya Santander-Nelli, Ramón López, Maria Isabel Menéndez, Int. J. Quantum Chem., special issue by Prof. Sylvio Canuto, 111 (2011) 1570-1582. ISI
  15. “Flow-Induced -Hairpin Folding of the Glycoprotein Iba -Switch”. Xueqing Zou, Yanxin Liu, Zhongzhou Chen, Gloria Inés Cárdenas-Jirón, Klaus Schulten, Biophys. J., 99 (2010) 1182-1191. ISI
  16. "A Theoretical Investigation on the Spectroscopic Properties and Photosensitizing Capability of 5, 10, 15, 20-tetraphenylsapphyrin and 5, 10, 15, 20-tetraphenyl-26,28-deheterosapphyrins with two O, S, or Se Atoms". Ramón López, M. Isabel Menéndez, Mireya Santander, Gloria I. Cárdenas-Jirón, Theor. Chem. Acc., 127 (2010) 475–484. ISI
  17. "A Computational Study on the Stability-Aromaticity Correlation of Triply N-Confused Porphyrins". Violeta Yeguas, Gloria Inés Cárdenas-Jirón, María Isabel Menéndez, Ramón López, J. Math. Chem., 48 (2010) 137-144. ISI
  18. “Synthesis and Reactivity of 5-tetramethylcyclopentadienyl-propenyl rhenium Complexes: Molecular Structure of [(5:2-C5Me4CH2CH=CH2)Re(CO)2]”. Fernando Godoy, Alejandra Gómez, Gloria Cárdenas-Jirón, A. Hugo Klahn, Fernando J. Lahoz, J. Organomet. Chem., 695 (2010) 346-351. ISI
  19. "Inhibitory Effect of Aromatic Geranyl Derivatives isolated from Heliotropium filifolium on Infectious Pancreatic Necrosis Virus Replication". Brenda Modak, Ana María Sandino, Loredana Arata, Gloria Cárdenas-Jirón, René Torres, Veterinary Microbiology, 141 (2010) 53-58. ISI
Proyectos: 
  • FONDECYT N°1131002 – CONICYT. Theoretical Assessment of the Photosensitization of Porphyrins Anchored on Titanium Dioxide and Organic Supports, Investigadora responsable, 2013 - 2016.
  • Proyecto Inserción de Capital Humano Avanzado en la Academia Nº 79100010. Fortalecimiento de las áreas de química orgánica y de polímeros en la docencia e investigación, Investigadora responsable, 2011 - 2013.
Email: 
cristhian.berrios@usach.cl
Teléfono: 
27 181 000
Sitio web: 
http://www.experts.scival.com/UdeSantiago/expert.asp?n=CRISTHIAN%20E%20BERRIOS%2…

Abstract

En el área de electroquímica trabajo en la preparación y uso de electrodos  modificados (carbono vítreo, ITO, titanio, electrodos metálicos, entre otros) con catalizadores para la degradación de compuestos orgánicos contaminantes. Entre los compuestos contaminantes ya estudiados se encuentran clorofenoles y antibióticos. Actualmente se está trabajando con dióxido de titanio como catalizador sobre una superficie electródica, también en el área de la fotoquímica en una suspensión, o usando ambas técnicas en conjunto a través de la electroquímica asistida por fotoquímica.

El utilizar dióxido de titanio no sólo permitir trabajar en el área de degradación de compuestos contaminantes, sino que también en la obtención de energía a través de celdas fotovoltáicas. Este es un tema interesante debido a los actuales problemas energéticos.

Línea(s) de investigación: 
Electrocatálisis, degradación de compuestos contaminantes, electrodos modificados.
Jerarquía: 
Asistente
Grados académicos /educación: 
Químico, Universidad de Santiago de Chile.
Doctor en Química, Universidad de Santiago de Chile
Publicaciones: 
  1. M.S. Ureta-Zañartu; C. Berríos; J. Pavez; C. Gutierrez; J.H. Zagal. "Electrooxidation of chloro-phenols catalyzed by electrodes modified with Ni(II)tetrasulfophthalocyanine". En "Energy and Electrochemical Processes for a Cleaner Environment". E.W. Brooman, C.M. Doyle and C. Comninellis eds. The Electrochemical Society Symposium Series" PV 2001-23, (2001) 448–460.
  2. M. S. Ureta-Zañartu; P. Bustos; C. Berríos; M. C. Diez; M. L. Mora; C. Gutiérrez. “Electrooxidation of 2,4-dichlorophenol and other polychlorinated phenols at a glassy carbon electrode”. Electrochim. Acta, 47 (2002) 2399–2406. ISI IF:3,642
  3. M. S. Ureta-Zañartu; M. L. Mora; M. C. Diez; C. Berríos; J. Ojeda; C. Gutiérrez. “Chlorophenol electrooxidation on iron oxide-covered aluminosilicates deposited on glassy carbon”. J. Appl. Electrochem., 32 (2002) 1211–1218. ISI IF: 1,494
  4. M. S. Ureta-Zañartu; C. Berríos; J. Pavez; J. Zagal; C. Gutiérrez; J. Marco. “Electrooxidation of 2-chlorophenol on polyNiTSPc-modified glassy carbon electrodes” J. Electroanal. Chem., 553 (2003) 147–156. ISI IF: 2,732
  5. M. S. Ureta-Zañartu, A. Alarcón, C. Berríos, G. I. Cárdenas-Jirón, J. Zagal, C. Gutiérrez. “Electropreparation and characterization of polyNiTSPc films. An EQCM study”. J. Electroanal. Chem., 580 (2005) 94–104. ISI IF: 2,732
  6. C. Berríos; G. I. Cárdenas-Jirón; J. F. Marco; C. Gutiérrez; M. S. Ureta-Zañartu. “Theoretical and spectroscopy study of Ni(II)-porphyrin derivatives”. J. Phys. Chem. A, 111 (2007) 2706–2714. ISI IF: 2,732
  7. C. Berríos; M. S. Ureta-Zañartu; C. Gutiérrez. “Impedance study of electropolimerized films of polyNi(II)-macrocycles”. Electrochim. Acta, 53 (2007) 792 – 802. ISI IF: 3,642
  8. C. Berríos; R. Arce; M.C. Rezende; M.S. Ureta-Zañartu; C. Gutiérrez. “Electrooxidation of chlorophenols at a glassy carbon electrode in a pH 11 buffer”. Electrochim. Acta, 53 (2008) 2768–2775. ISI IF: 3,642
  9. Gloria I. Cárdenas-Jirón; Cristhian Berríos. “Theoretical evidence of the Ni(III) participation in the chlorophenol oxidation on tetrasulphonated nickel phthalocyanine”.  Int. J. Quant. Chem., 108 (2008) 2586 – 2594. ISI IF: 1,302
  10. Cristhian Berríos; José F. Marco; Claudio Gutiérrez; María Soledad Ureta-Zañartu. “Study by XPS and UV-visible and DRIFT spectroscopies of electropolymerized films of substituted Ni(II) phenylporphyrins and phthalocyanines” J. Phys. Chem. B, 112 (2008) 12644 – 12649. ISI IF: 3,603
  11. Cristhian Berríos; José F. Marco; Claudio Gutiérrez; María Soledad Ureta-Zañartu. “Electro-oxidation of chlorophenols at glassy carbón electrodes modified with polyNi(II)complexes”. Electrochim. Acta, 54 (2009) 6417 – 6425. ISI IF: 3,642
  12. Luis Cortez; Cristhian Berríos; Mauricio Yañez; Gloria I. Cárdenas-Jirón. “Theoretical study of the binding nature of glassy carbón with nickel(II) phthalocyanine complexes”. Chem. Phys., 365 (2009) 164 – 169. ISI IF: 2,017
  13. María Soledad Ureta-Zañartu; Thaís González; Francisco Fernández; Daniela Báez; Cristhian Berríos; Claudio Gutiérrez. “Electro-Oxidation of Benzyl and Aliphatic Alcohols on polyNiTSPc- and Ni(OH)2-Modified Glassy-Carbon and Gold Electrodes”.  Int. J. Electrochem. Sci., 7 (2012) 8794 – 8812. ISI IF: 3,729
  14. María Soledad Ureta-Zañartu, Cristhian Berríos, Thaís González, Francisco Fernández, Daniela Báez, Ricardo Salazar, Claudio Gutiérrez.  “Electrocatalytic Oxidation of Alcohols at Gold Electrodes in Alkaline Media”. Int. J. Electrochem. Sci., 7 (2012) 8905 – 8928. ISI IF: 3,729
Proyectos: 
  1. 2009, FONDECYT N°11090336, Investigador responsable. “Electrochemically Assisted Photocatalysis Degradation of Organics Contaminant in Water over Modified Electrode with TiO2”. Oct 2009 – sept2012. Investigador responsable

     
  2. 2008, Bicentenario PDA-03 Inserción en la Academia, CONICYT–USACH, Post-doctorado. “Degradación Electroquímica y Fotoquímica de Fármacos Contaminantes en Aguas sobre Electrodos Modificados con TiO2”. Nov. 2008 – Nov. 2011.
Otras actividades relevantes: 

Número de tesis dirigidas en los últimos 10 años: 

Magister:                   En desarrollo:             01

Email: 
alexis.aspee@usach.cl
Teléfono: 
27 181 133

Abstract

The extent of the oxidative damage induced by reactive oxygen species (ROS) in biological systems depends on a variety of factors that include the location of the target molecule with respect to the site of ROS formation, the reaction's rate constant, and the presence of antioxidants capable of ROS scavenging and/or repairing the initial damaged molecule. The complexity of these processes requires the development of new tools and strategies to pinpoint the free radical processes affecting a biological system. During the last few years our group has focused its research on developing new strategies to study free radical processes and mechanisms involved in amino acid and protein oxidation, such as spontaneous weak level chemiluminescence. Recently, we developed and applied nitroxide pre-fluorescent probes to monitor free radical formation in a wide variety of chemical systems, including zeolites, polymer films, and proteins. Furthermore, the use of these probes was extended to evaluate polyphenolic antioxidants in hydrogen and/or electron transfer-based reactions towards nitroxides, both in homogeneous and in microheterogeneous systems. These methodologies have allowed us to understand better antioxidant and free radical oxidation mechanisms in complex systems in concomitance with the use of time resolve techniques to monitor transient and free radical formation photoinduced by laser excitation of molecular probes and their reaction with proteins, amino acids, and also nitroxide and phenolic antioxidants.

Líneas de investigación

Durante los últimos años, nuestro grupo ha centrado su investigación en el desarrollo de nuevas estrategias para estudiar los procesos y mecanismos de radicales libres implicados en la oxidación de aminoácidos y proteínas, como la quimioluminiscencia espontánea de nivel débil. Recientemente, desarrollamos y aplicamos sondas pre-fluorescentes de nitróxido para monitorear la formación de radicales libres en una amplia variedad de sistemas químicos, incluidas zeolitas, películas poliméricas y proteínas. Además, el uso de estas sondas se amplió para evaluar antioxidantes polifenólicos en reacciones basadas en transferencia de hidrógeno y / o electrones hacia nitróxidos, tanto en sistemas homogéneos como microheterogéneos. Estas metodologías nos han permitido comprender mejor los mecanismos de oxidación de radicales libres y antioxidantes en sistemas complejos en concomitancia con el uso de técnicas de resolución temporal para monitorear la formación de radicales libres y transitorios fotoinducidos por excitación láser de sondas moleculares y su reacción con proteínas, aminoácidos y también nitróxido y antioxidantes fenólicos.

 

Jerarquía: 
Asociado
Grados académicos /educación: 
Químico, Universidad de Santiago de Chile, 1994
Doctor en Química, Universidad de Santiago de Chile, 2000 Postdoctorado: University of Ottawa, Canadá, 2001-2003
Publicaciones: 
  • L. Scarpetta-Pizo, R. Venegas, P. Barrías, K. Muñoz-Becerra, N. Vilches-Labbé, F. Mura, A. M. Méndez-Torres, R. Ramírez-Tagle, A. Toro-Labbé, S. Hevia, J. H. Zagal, R. Oñate, A. Aspée, I. Ponce, Electron Spin-Dependent Electrocatalysis for the Oxygen Reduction Reaction in a Chiro-Self-Assembled Iron Phthalocyanine Device, Angew. Chem. Int. Ed. 2023, 62, e202315146.
  • Zúñiga-Núñez, D., Mura, F., Mariño-Ocampo, N., Briones-Rebolledo, P., Poblete, H., Mallet, J-M., Fuentealba, D., Aspée, A. Time-resolved fluorescence and anisotropy-sensitive 1,2-dimyristoyl-snglycero-3-(7-aminocoumarin) phosphoetanolamide probe for studying membrane lipid domains, Dyes and Pigments, 2023, 111368, https://doi.org/10.1016/j.dyepig.2023.111368.
  • Orellana-Maldonado, I., Aspée, A., Barrias, P., Santana, P. A., Tirapegui, C., Photoswitching studies of new photochromic ionic liquids studied in real time by in situ irradiation, New J. Chem., 2022,46, 12825-12835, https://doi-org.ezproxy.usach.cl/10.1039/D2NJ01194H.
  • Cortés-Quezada, M., Parada, A.M., Videla, X., Valdés, J. A., Gonzalez-Catrilelbún, S., Aspée, A., Nario, A., Rivas-Aravena, A., Labelling fish diets with 15 N -Leucine for monitoring feed consumption and bio-distribution in Atlantic salmon, Vet Med Sci. 2022;1 8. DOI: 10.1002/vms3.730.
  • Bridi R, Gonzalez A, Bordeu E, Lopez-Alarcon C, Aspee A, Diethelm B, Lissi E, Parpinello GP, Versari A. Monitoring peroxides generation during model wine fermentation by FOX-1 assay. Food Chem. 175, 25-28 (2015) ISI 2014: 3.391. DOI: 10.1016/j.foodchem.2014.11.126.
  • E. Dorta, E. Fuentes-Lemus, A. Aspee, E. Atala, H. Speisky, R. Bridi, E. Lissi, C. Lopez- Alarcon, The ORAC (oxygen radical absorbance capacity) index does not reflect the capacity of antioxidants to trap peroxyl radicals, RSC Adv. 5, 39899-39902 (2015) ISI 2014: 3.84. DOI: 10.1039/C5RA01645B
  • M. Liras, S. Simoncelli, A. Rivas-Aravena, O. Garcia, J. C. Scaiano, E. I. Alarcon, A. Aspee, Nitroxide amide-BODIPY probe behavior in fibroblasts analyzed by advanced fluorescence microscopy, Organic & Biomolecular Chemistry, (2016), 14, 4023 - 4026. ISI 2014: 3.562. DOI: 10.1039/C6OB00533K
  • E. Fuentes-Lemus, E. Dorta, E. Escobar, A. Aspee, E. Pino, M. L. Abasq, H. Speisky, E. Silva, E. Lissi, M. J. Davies, C. Lopez-Alarcon, Oxidation of free, peptide and protein tryptophan residues mediated by AAPH-derived free radicals: role of alkoxyl and peroxyl radicals, RSC Adv.(2016) 6, 57948. ISI 2014: 3.84. 10.1039/C6RA12859A
  • J. Benavides, P. Barrias, N. Piro, A. Arenas, A. Orrego, E. Pino, L. Villegas, E. Dorta, A. Aspee⁎, C. Lopez-Alarcon⁎. Reaction of tetracycline with biologically relevant chloramines, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, (2017), 178, 171–180. ISI 2014: 2.353. DOI: 10.1016/j.biopha.2017.03.082
  • E. Dorta, A. Aspee, E. Pino, L. Gonzalez, E. Lissi, C. Lopez-Alarcon, Controversial alkoxyl and peroxyl radical scavenging activity of the tryptophan metabolite 3-hydroxy-anthranilic acid, Biomedicine & Pharmacotherapy, (2017), 90, 332-338. ISI 2014: 2.023
  • A. Aspee, C. Aliaga, L. D. Zuniga-Nunez, J. Godoy, E. Pino, G. Cardenas-Jiron, C. Lopez- Alarcon, JC Scaiano, EI Alarcon, Reaction Kinetics of Phenolic Antioxidants Towards Photo- Induced Pyranine Free Radicals in Biological Models, J. Phys. Chem. B. (2017), 121, 6331-6340. ISI 2014: 3.302. DOI: 10.1021/acs.jpcb.7b02779
  • Daniel Zuniga-Nunez, Pablo Barrias, Gloria Cardenas-Jiron, M. Soledad Ureta-Zanartu, Camilo Lopez-Alarcon, F. Eduardo Moran Vieyra, Claudio D. Borsarelli, Emilio I. Alarcon, Alexis Aspee*, Atypical antioxidant activity of non-phenolic amino-coumarins, RSC Adv. (2018), 8, 1927-1933. ISI 2014: 3.84 DOI: 10.1039/C7RA12000A
  • Fuentes-Lemus E, Silva E, Barrias P, Aspee A, Escobar E, Lorentzen LG, Carroll L, Leinisch F, Davies MJ, Lopez-Alarcon C. Aggregation of α- and β- caseins induced by peroxyl radicals involves secondary reactions of carbonyl compounds as well as di-tyrosine and di-tryptophan formation. Free Radic Biol Med. (2018), 124, 176-188. ISI 2014: 5.784 doi: 10.1016/j.freeradbiomed.2018.06.005.
  • Daniel Zuniga-Nunez, Ricardo A. Zamora, Pablo Barrias, Cristian Tirapegui, Horacio Poblete, Gloria Cardenas-Jiron, Emilio I. Alarcon, Alexis Aspee. Theoretical rationalisation of the photophysics of a TICT excited state of cinnamoyl–coumarin derivatives in homogeneous and biological membrane models, Phys Chem Chem Phys. (2018) Nov 7;20(43):27621-27629. doi: 10.1039/c8cp04963g.
  • E. Silva, P. Barrias, E. Fuentes-Lemus, C.Tirapegui, A. Aspee, L. Carroll, M. J. Davies, C. Lopez-Alarcon, Riboflavin-induced Type 1 photo-oxidation of tryptophan using a high intensity 365‚ nm light emitting diode, Free Radical Biology and Medicine, (2019), 131, 133-143. https://doi.org/10.1016/j.freeradbiomed.2018.11.026
  • Francisco Mura, Daniel Zuniga-Nunez, Jean-Maurice Mallet, Solange Lavielle, Pascal Matton, Pablo Barrias, Denis Fuentealba, Alexis Aspee, A microenvironment-sensitive coumarinlabeled peptide for the assessment of lipid-peptide interactions, Dyes and Pigments (2020), 176, 108234
  • Zamora RA, Fuentes-Lemus E, Barrias P, Herrera-Morande A, Mura F, Guixe V, Castro- Fernandez V, Rojas T, Lopez-Alarcon C, Aguirre P, Rivas-Aravena A, Aspee A., Free 11 radicals derived from γ-radiolysis of water and AAPH thermolysis mediate oxidative crosslinking of eGFP involving Tyr-Tyr and Tyr-Cys bonds: the fluorescence of the protein is conserved only towards peroxyl radicals. Free Radic Biol Med. (2020) Feb 17;150:40-52
  • Zúniga-Nunez, D, Mura, F., Zamora, R. A., Poblete, H., Fuentealba, D., Aspee, A. Cinnamoyl– coumarin hybrid derivatives with remarkable fluorescent molecular-rotor properties in mixtures of DPPC:DOPC LUVs, Dyes and Pigments 178 (2020) 108356.
  • Castro, J., Fernandez, F., Olivares, F., Berrios, C., Garrido-Ramirez, E., Blanco, E., Escalona, N., Aspee, A., Barrias, P., Ureta-Zanart, M. S. Electrodes based on zeolites modified with cobalt and/or molybdenum for pesticide degradation: part II—2,4,6-trichlorophenol degradation, J. Solid State Electrochem. (2020) https://doi.org/10.1007/s10008-020-04590-6
  • Reyes, J.S., Fuentes-Lemus, E., Aspee, A., Davies, M. J., Monasterio, O., Lopez-Alarcon, C. M. jannaschii FtsZ, a key protein in bacterial cell division, is inactivated by peroxyl radicalmediated methionine oxidation, Free Radic Biol Med. 166 (2021) 53-66. doi: 10.1016/j.freeradbiomed.2021.02.003.

 

Proyectos: 
  • 2021-2025 FONDECYT 1211351 (Co-investigador) Interplay between Molecular Electronics and Electrocatalysis: Electrocatalytic Self-assembled systems as "supramolecular nano-devices" for applications in clean energy conversion.
  • 2022-2026 FONDECYT 1220459 (Co-investigador) Dimers and Heterodimers of Tryptophan and Tyrosine as Biomarkers of Protein Oxidation: Analytical Approaches for their Quantification in Isolated Proteins, Cell Extracts and C. Elegans Worms
  • 2023-2026 FONDECYT 1231468 (Investigador Principal) Evaluation of conformational dynamic aspects on the oxidation of antimicrobial-inspired peptides in phospholipid membranes by fast photoinduced free radical generation
  • 2015 FONDEQUIP EQM 150084 GC MS MS Plataforma de Cromatografía de Gases acoplada a espectrometría de Masa/Masa para el desarrollo de investigación multidisciplinar en la Universidad de Santiago de Chile en el estudio de compuestos volátiles en problemáticas transversales.
  • 2014-2018 FONDECYT-Chile 1140240 (Principal Investigador) Photoinduced free radicals and excited triplet states formation in organised biological mimetic systems.
  • 2014-2018 FONDECYT-Chile 1141142 (Co-investigador) Role of tryptophan residues in the aggregation and fragmentation of peptides and proteins induced by peroxyl and carbón centered radicals.
  • 2013 FONDEQUIP EQM 120065 UHPLC MSMS. Mejoramiento de equipamiento para detección de intermediarios y productos de reacción para los grupos de investigación de Cinética Química y Electroquímica de la Universidad de Santiago de Chile
  • 2013-2015 FONDECYT-3130697 Postdoctorado /Dr. Christian Aliaga (Patrocinante) Photochemistry of organic molecules in homogeneous and constrained media
  • 2017-2019 FONDECYT-3170590 Postdoctorado /Dr. Francisco Mura (Patrocinante) Nueva perspectiva de sondas duales nitróxido-fluoróforo en péptidos: estudio de su interacción con bicapas lipídicas.
  • 2017-2021 FONDECYT-1170842 (Co-investigador) Enhancement of endothelium signaling by dietary polyphenols and potassium supplements in control and STZdiabetic rats.
  • 2018-2022 FONDECYT-1180642 (Co-investigador) Oxidative modifications induced by carbonate radical, nitrogen dioxide, and peroxyl radicals on two enzymes of the pentose phosphate pathway: consequences on NADPH release and reduced glutathione recycling.
  • 2019-2023 FONDECYT-1190881 (Principal Investigador) Electron transfer processes in peptides induced by free radicals: Influence of the amino acid sequence, peptide conformation and microenvironment.
Email: 
iriux.almodovar@usach.cl
Teléfono: 
27 181 161
Sitio web: 
http://www.experts.scival.com/UdeSantiago/expert.asp?n=IRIUX%20ALMODOVAR%20FAJAR…

Abstract

Developing of green synthetic strategies to obtain compounds with interesting pharmacological properties.

Línea(s) de investigación: 
Síntesis Orgánica - Mecanismos de reacción, Química Verde
Jerarquía: 
Asistente
Grados académicos /educación: 
Químico, Universidad de La Habana, 1996
Doctor en Química, Universidad de Chile, 2006.
Publicaciones: 

  • Jorge Ariel Saavedra-Olavarría*, Patricio Hermosilla-Ibáñez, Edwin G. Pérez, and Iriux Almodóvar (2022), “Fast Heating-Assisted One-pot Copper-Catalysed Sulfonylation and Sulfochlorination of Styrenes” Eur. J. Org. Chem. 2022, e202101526. (IF=3,021)

  • Arteaga, Gean C.; Saavedra-Olavarria, Jorge; Almendras, Sebastian; Hermosilla-Ibanez, Patricio; Almodovar, Iriux; Perez, Edwin G.* Copper-catalyzed intermolecular aminochlorination of alkenes. Tetrahedron Letters, 2018, 59, (12),191-193 (IF=2.415)

  • Saavedra-Olavarria, Jorge; Madrid-Rojas, Matias; Almodovar, Iriux; Hermosilla-Ibanez, Patricio; Perez, Edwin G*. Synthesis of beta-alkoxy-N-protected phenethylamines via one-pot copper-catalyzed aziridination and ring opening. RSC Advances, 2018, 8, (49), 27919-27923 (IF=3.390)

  • Almodovar, Iriux*; Caroli Rezende, Marcos; Cassels, Bruce K.; Garcia-Arriagada, Macarena, Theoretical insights into the regioselectivity of a Pictet-Spengler reaction: Transition state structures leading to salsolinol and isosalsolinol, JOURNAL OF PHYSICAL ORGANIC CHEMISTRY, 2017, 30 (8) (IF=2.391)

  • C. Aliaga, I. Almodovar and M. C. Rezende, A single theoretical descriptor for the bond-dissociation energy of substituted phenols, J. Mol. Model., 21 (2015), 2572. Impact Factor=1.867I.

  • M. C. Rezende, I. Ponce, R. Oñate, I. Almodovar, C. Aliaga. Change of mechanism with a change of substituents for a Zincke reaction. Tetrahedron Letters 55 (2014) 3097. Impact Factor= 2.397.

  • P. Abarca, P. Silva, I. Almodovar, M. C. Rezende* Preparation and properties of perichromic dye: an undergraduate laboratory, Quim. Nova, 37(4) (2014) 745. Impact Factor =0.737.

  • I. Almodovar*, T. Delgado-Castro, G. Zapata-Torres, M. C Rezende, R. Araya-Maturana, Factors affecting the competitive reduction of 8,8-dimethylnaphthalene-1,4,5(8H)-trione in a Diels-Alder cycloaddition with hydroxysulfinyldienes. J.Iran.Chem.Soc., (2014), Volume 11, Issue 4, 1021-1026 . Impact Factor= 1.467.

  • I. Almodovar*, W. Cardona, T. Delgado-Castro, G. Zapata-Torres, M. C. Rezende, R. Araya-Maturana, M. C. Maestro, J. L. García Ruano, Remote regio- and stereocontrol by the sulfinyl group. Diels-Alder reaction of sulfinyl dienols and 8,8-dimethylnaphthalene-1,4,5(8H)-trione. Tetrahedron: Asymmetry, 24 (2013) 56. Impact Factor= 2.652.

  • M. A. Juricic*, P. A. Berríos-Cárcamo, M. L. Acevedo, Y. Israel, I. Almodovar, B. K. Cassels, Salsolinol and isosalsolinol: condensation products of acetaldehyde and dopamine.Separation of their enantiomers in the presence of a large excess of dopamine. Journal of pharmaceutical and biomedical analysis, 63 (2012) 170. Impact Factor=2.723.

  • M. C. Rezende*, I. Almodovar, Substituent electrophilicities in the NMR spectra of barbituric Derivatives, Magnetic Resonance in Chemistry, 50 (2012) 266. IF= 1,247.

  • H. Pessoa-Mahana*, I. M. Cuevas, D. C. Pessoa-Mahana, R. Araya-Maturana, I. Almodovar and C. A. Saitz-Barrá, Synthesis of 1-Benzyl-3-[4-(Aryl-1-Piperazinyl) Carbonyl]-1h-Indoles: Novel Ligands With Potential D4 Dopaminergic Activity. Journal of Chilean Chemical Society, 56, 4 (2011) 866. Impact Factor= 0.448.

  • I. Almodovar*, O. Ramírez-Rodríguez, A. Barriga, M. C. Rezende, R. Araya-Maturana, Electrospray ionization mass spectrometric fragmentation of hydroquinone derivatives. Rapid Commun. Mass Spectrom. 25 (2) (2011) 370. Impact Factor=2.846.

Capítulo de Libro:

Sandra Patricia Rojas Rojas , Iriux Almodovar, Ignacio Tapia, Nicolás Troncoso and David Leal,” “Promoción de habilidades de pensamiento científico y el diagrama heurístico en las actividades de laboratorio de Química Orgánica I. Experiencia en la formación de futuros profesores de química y biología.” Innovar y Transformar desde las Disciplinas: Experiencias claves en la Educación Superior en América Latina y El Caribe 2021-2022 https://doi.org/10.34720/zmdk-a274

Proyectos: 
No1211619 ,Co-investigadora,  (ANID 2021-2025)

No 018-2018, Investigadora Principal  (PID, VRA Marzo 2019- Agosto 2020)

No 012-2018, Co-investigadora  (PID, VRA, Marzo 2019- Agosto 2020)

No 1171391, Co-investigadora (FONDECYT 2017-2021)

021641AF, Investigadora responsable (DICYT 2016-2019)

Nº 11121270 (Iniciación).  Investigadora Principal. 2012 - 2015.

 
Nº 3100059 (Postdoctorado). Investigadora Principal. 2009 - 2012.
Email: 
carolina.aliaga@usach.cl
Teléfono: 
27 181 131
Sitio web: 
http://www.experts.scival.com/UdeSantiago/expert.asp?n=CAROLINA%20D.P.%20ALIAGA%…
Abstract

We develop a novel series of pre-fluorescent compounds based on pyridinium salts with different hydrophobicity and spectral behavior attached to a nitroxyl moiety. 
The activity of these new probes are monitored by fluorescence and/or EPR spectroscopy.
We also investigate the importance of the distribution of the probe and substrate in microheterogeneous media in hydrogen-transfer reactions. We are interested in to study the distribution of these compounds depending on their hydrophobicities, an aspect which has been systematically ignored in previous evaluations of antioxidant activities. By employing a series of nitroxide derivatives and probes of variable hydrophobicities  we will be able to measure these effects in a systematic way. We hope to arrive at a more rigorous model for medium effects on hydrogen-transfer processes.
We also investigate the hydrogen transfer process by directly monitoring nitroxides with phenols with different hydrophobicities by employing electronic spin resonance techniques.

Línea(s) de investigación: 
Reactividad y Cinética de Reacciones de Radicales Libres con especies donoras de Hidrogeno. Caracterización de especies radicales Orgánicas e Inorgánicas.
Jerarquía: 
Investigador Asociado, Vicerrectoria de Investigación y Desarrollo.
Grados académicos /educación: 
Profesora de Química y Ciencias Naturales
Doctora en Química
Publicaciones: 
  • C. Aliaga, F. Bravo-Moraga, D. Gonzalez-Nilo, S. Márquez, S. Lühr, G. Mena, M. C. Rezende. “Location of TEMPO derivatives in micelles: subtle effect of the probe orientation” Food Chemistry, (2016), 192, 395-401.
  • C. Aliaga, F. Celis, S. Lühr, R. Oñate “TEMPO-Attached Pre-fluorescent Probes Based on Pyridinium Fluorophores” J. Fluorescence (2015) 25, 979-983.
  • C. Aliaga, I. Almodovar and M. C. Rezende “A single theoretical descriptor for the bond-dissociation energy of substituted phenols” J Mol Model (2015) 21: 12 DOI 10.1007/s00894-015-2572-x.
  • A. B. Oliveira, R. L. Rodriguez-Suarez, S. Michea, H. Vega, A. Azevedo, S. M. Rezende, C. Aliaga, and J. Denardin. “Angular dependence of hysteresis shift in oblique deposited ferromagnetic/antiferromagnetic coupled bilayers” Journal of Applied Physics 116 (2014) 033910. doi: 10.1063/1.4890457.
  • M.C. Rezende, I. Ponce, R. Oñate. I. Almodóvar, C. Aliaga. Change Of Mechanism With A Change Of Substituents For A Zincke Reaction Tetrahedron Letters 55 (2014) 3097–3099.
  • C. Aliaga*, M.C. Rezende, “EPR spectrum of a radical from a non typical antioxidant”, Magn. Resn. Chem. 52, (2014) 409–411 DOI: 10.1002/mrc.4070
  • C. Aliaga*, P.Fuentealba, M. C Rezende, C. Cárdenas “Mechanism of fluorophore quenching in a pre-fluorescent nitroxide probe: a theoretical illustration.” Chem. Phys. Lett. 593 (2014) 89–92.
  • R.L. Rodríguez-Suárez, J.L. Palma, E.O. Burgos, S. Michea, J. Escrig, J.C. Denardin, C. Aliaga. “Ferromagnetic resonance investigation in permalloy magnetic antidot arrays on alumina nanoporous membranes” J. Magnetism Magnetic Mat, 350 (2014) 88-93.
  • E. I. Alarcon, A. Aspee, C. Aliaga S. E. Braslavsky, “Special Issue Dedicated to the Memory of Elsa Beatriz Abuin Saccomano (1942–2012)” Photochem. Photobiol., 89 (2013) 1270–1272.
  • C. Aliaga, P.Torres and F. Silva. “A simple method for the determination of the partitioning of nitroxide probes in microheterogeneous media” Magn. Resn. Chem., 50 (2012) 779-783
  • D. Venegas-Yazigi, K. Brown, A. Vega, R. Calvo, C. Aliaga, R. Santana, R. Cardoso-Gil, R. Kniep, W. Schnelle, E. Spodine. "Exchange Interactions Through π-π Stacking in the Lamellar Compound [{Cu(bipy)(en)}{Cu(bipy)(H2O)}{VO3}4]n" Inorganic Chemistry. 50 (2011) 11461–11471.
  • M. C. Rezende, C. Mascayano, L. Briones, C. Aliaga. “Sensing different micellar microenvironments with solvatochromic dyes of variable lipophilicity” Dyes and Pigment, 90 (2011) 219-224
  • R. Bridi, C. Aliaga, A. Aspee, E. Abuin, and E. A. Lissi. “Distribution and reactivity of gallates toward galvinoxyl radicals in SDS micellar solutions. Effect of the alkyl chain length” Can. J. Chem. 89, (2011) 181-185.
  • C. Aliaga, L. Briones, M.C. Rezende, C. Tirapegui. “The thermochromism of the ET(30) betaine in a micro-heterogeneous medium: a spectral and dynamics simulation study” J. Coll. Int. Sci., 349 (2010) 565–570.
  • D. Venegas-Yazigi, K. Muñoz-Becerra, E. Spodine, K. Brown, C. Aliaga, V. Paredes-García, P. Aguirre, A. Vega, R. Cardoso-Gil, W. Schnelle, R. Kniep. Magnetic and Catalytic Properties of the 2D Copper (II) Functionalized VPO Hybrid System [{Cu(bpy)}2(VO)3(PO4)2(HPO4)2]·2H2O, Polyhedron 29 (2010) 2426-2434
  • C. Aliaga*, M.C. Rezende and C. Tirapegui “A new probe for hydrogen abstraction and radical detection” Tetrahedron 65 (2009) 6025–6028.

 

Proyectos: 

Investigador responsable

  1. FONDECYT  1110736 “Design and properties of new prefluorescent probes in homo and microhetero-geneous media”, 2011-2014
  2. FONDECYT 1080234 “Use of prefluorescent and radical probes for the study of medium effects on hydrogen transfer reactions”, 2008-2010
  3. DICYT- USACH “Detección de especies radicalarias por técnicas de resonancia de espín electrónico (ESR) en sistemas de interés biológico”. USACH, 2006-2007
  4. Inserción de Investigadores/as postdoctorales -World Bank. Microscopías y Espectroscopías. USACH-CONICYT, 2005-2007

Co-Investigador

 

  1. FONDECYT (1140212) "Perichromic dyes in homogeneous media and adsorbed on nanoparticles", 2014 - 2018
  2. Proyecto FONDEF (PROGRAMA IDeA De FONDEF‐CONICYT ) CA12i10116 Determinación de dosis de radiación aplicada  a alimentos por Resonancia de Spin Electrónico (ESR ), 2012-2015.
  3. Proyecto Basal-CONICYT FB0807, Centro para el Desarrollo de la Nanociencia y la Nanotecnología, CEDENNA (Investigador Asociado, Linea 4) 2009-201

Investigador Asociado

  1. DICYT 021541ª, USACH. Anillo. “Inorganic Polyfunctional Materials Based on Chilean Strategic Metals. IPMaG". 2015 - 2017

PROGRAMA DE INVESTIGACION ASOCIATIVA. CONICYT, Anillo "Inorganic Polyfunctional Materials Based on Chilean Strategic Metals. IPMaG", 2015 - 2017. 

Otras actividades relevantes: 

Número de tesis dirigidas en los últimos 10 años:

Doctorado:       Dirigidas: 1             En desarrollo:             1

 

Referee de revistas internacionales

  1. Photochemistry and Photobiology 
  2. Food Chemistry

 

Revisor de proyectos

  1. FONDECYT Regulares
  2. FONDECYT Posdoctoral
  3. FONDECYT Iniciación
  4. FONDEQUIP
  5. DICYT

Par evaluador de Postgrado

  • Programa de Doctorado en Química, Universidad de Chile

 

Comité de sociedades científicas

  1. Miembro de la Royal Society of Chemistry
  2. Miembro de la Photochemistry and Photobiology Society

 

Participación en claustro de doctorados

  • Doctorado en Química

Requisito de postulación

Enviado por jaime.quiroga en Mar, 06/04/2013 - 20:10

Requisitos previos para el Curso de Fundamentos de Química y Matemática Básica para el Laboratorio: Licencia de Enseñanza Media

Requisitos previos para el Ingreso de la Carrera del Técnico Universitario en  Análisis Químico y Físico (TUAQF): Aquellos alumnos que estén interesados en ingresar vía especial a la  Carrera del TUAQF deben aprobar el curso Fundamentos de Química y Matemática Básica para el Laboratorio y deben acreditar además antigüedad laboral mínima de dos años en trabajos relacionados con el área de química o afines y un año para egresados de la enseñanza media técnico profesional del área química.

Información complementaria

Enviado por jaime.quiroga en Mar, 06/04/2013 - 20:02

AActividad de capacitación autorizada por el SENCE para los efectos de la franquicia tributaria  de capacitación, no conducente al otorgamiento de un título o grado académico.

Información General:
OTEC:Capacitación Usach Compañía Ltda.,  
Rut: 76.421.320-3, Registro: 27305
Avda. Libertador Bernardo O’Higgins 1611, fono: 271 81448
Lugar de Realización:    Universidad de Santiago de Chile, Facultad de Química y Biología, Avda. Libertador Bernardo O’Higgins 3363,
Duración: 60 Horas Cronológicas
Código SENCE:12-37-8351-78  
Valor Curso:$ 350.000 (Sence cubre parcialmente este curso  con $240.000)
Días de Clases / Horario: Lunes a jueves/  19:00 - 22:00 hrs.
Inicio / Término: 20 de junio de 2016 hasta el 25 de julio de 2016
 

Contactarse con: Jeanette Espíndola A : jeanette.espindola@usach.cl 02-27181005 /Mariela Villarroel A: mariela.villarroel@usach.cl   02-27181078
 

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